Combined Inflammatory and Metabolic Defects Reflected by Reduced Serum Protein Levels in Patients with Buruli Ulcer Disease

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dc.contributor.authorPhillips, Richard Odame
dc.contributor.authorSarfo, Fred Stephen
dc.contributor.authorLandier, Jordi
dc.contributor.authorOldenburg, Reid
dc.contributor.authorFrimpong, Michael
dc.contributor.authoret. al
dc.date.accessioned2020-01-09T16:15:16Z
dc.date.accessioned2023-04-19T01:41:52Z
dc.date.available2020-01-09T16:15:16Z
dc.date.available2023-04-19T01:41:52Z
dc.date.issued2014-04-10
dc.descriptionAn article published by PLOS Neglected Tropical Diseases and available at doi:10.1371/journal.pntd.0002786en_US
dc.description.abstractBuruli ulcer is a skin disease caused by Mycobacterium ulcerans that is spreading in tropical countries, with major public health and economic implications in West Africa. Multi-analyte profiling of serum proteins in patients and endemic controls revealed that Buruli ulcer disease down-regulates the circulating levels of a large array of inflammatory mediators, without impacting on the leukocyte composition of peripheral blood. Notably, several proteins contributing to acute phase reaction, lipid metabolism, coagulation and tissue remodelling were also impacted. Their down-regulation was selective and persisted after the elimination of bacteria with antibiotic therapy. It involved proteins with various functions and origins, suggesting that M. ulcerans infection causes global and chronic defects in the host’s protein metabolism. Accordingly, patients had reduced levels of total serum proteins and blood urea, in the absence of signs of malnutrition, or functional failure of liver or kidney. Interestingly, slow healers had deeper metabolic and coagulation defects at the start of antibiotic therapy. In addition to providing novel insight into Buruli ulcer pathogenesis, our study therefore identifies a unique proteomic signature for this disease.en_US
dc.description.sponsorshipKNUSTen_US
dc.identifier.citationPLoS Negl Trop Dis 8(4): e2786. doi:10.1371/journal.pntd.0002786en_US
dc.identifier.urihttps://ir.knust.edu.gh/handle/123456789/11877
dc.language.isoenen_US
dc.publisherPLOS Neglected Tropical Diseasesen_US
dc.titleCombined Inflammatory and Metabolic Defects Reflected by Reduced Serum Protein Levels in Patients with Buruli Ulcer Diseaseen_US
dc.typeArticleen_US
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