Cytotoxic T Cell-Derived Granzyme B Is Increased in Severe Plasmodium Falciparum Malaria
dc.contributor.author | Kaminski Lea-Christina | |
dc.contributor.author | Riehn Mathias | |
dc.contributor.author | Owusu-Dabo Ellis | |
dc.contributor.author | Abel Annemieke | |
dc.contributor.author | Steeg Christiane....et al | |
dc.contributor.orcid | 0000-0003-4232-4292 | |
dc.date.accessioned | 2023-12-13T16:14:45Z | |
dc.date.available | 2023-12-13T16:14:45Z | |
dc.date.issued | 2019 | |
dc.description | This article is published by Frontiers in Immunology and is also at https://doi.org/10.3389/fimmu.2019.02917ailable at | |
dc.description.abstract | In Plasmodium falciparum malaria, CD8+ T cells play a double-edged role. Liver-stage specific CD8+ T cells can confer protection, as has been shown in several vaccine studies. Blood-stage specific CD8+ T cells, on the other hand, contribute to the development of cerebral malaria in murine models of malaria. The role of CD8+ T cells in humans during the blood-stage of P. falciparum remains unclear. As part of a cross-sectional malaria study in Ghana, granzyme B levels and CD8+ T cells phenotypes were compared in the peripheral blood of children with complicated malaria, uncomplicated malaria, afebrile but asymptomatically infected children and non-infected children. Granzyme B levels in the plasma were significantly higher in children with febrile malaria than in afebrile children. CD8+ T cells were the main T cell subset expressing granzyme B. The proportion of granzyme B+ CD8+ T cells was significantly higher in children with complicated malaria than in uncomplicated malaria, whereas the activation marker CD38 on CD8+ T cells showed similar expression levels. This suggests a pathogenic role of cytotoxic CD8+ T cells in the development of malaria complications in humans. | |
dc.description.sponsorship | KNUST | |
dc.identifier.citation | Front. Immunol., 11 December 2019 Sec. Microbial Immunology Volume 10 - 2019 | https://doi.org/10.3389/fimmu.2019.02917 | |
dc.identifier.uri | 10.3389/fimmu.2019.02917 | |
dc.identifier.uri | https://ir.knust.edu.gh/handle/123456789/14839 | |
dc.language.iso | en | |
dc.publisher | Frontiers in Immunology | |
dc.title | Cytotoxic T Cell-Derived Granzyme B Is Increased in Severe Plasmodium Falciparum Malaria | |
dc.type | Article |
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