Genotypic characterisation of human papillomavirus infections among persons living with HIV infection; a case–control study in Kumasi, Ghana
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Date
2015
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Journal ISSN
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Tropical Medicine and International Health
Abstract
The objective of this study is to describe the burden of human papillomavirus (HPV)
infection among women living with HIV and non-infected women in Ghana.
methods A case–control study was conducted involving 107 women living with HIV aged between
18 and 59 years (cases) and 100 non-HIV-infected apparently healthy women (controls) who were
recruited from the Kumasi South Hospital, from July to December, 2014. Cervicovaginal swabs were
taken from study participants to characterise 28 high- and low-risk HPV genotypes using a multiplex
real-time PCR.
results The overall mean age for the participants was 40.10 9.76 years. The prevalence of high risk
(hr)-HPV genotypes was significantly higher among the cases than the controls (77.4% vs.
41.6%, P < 0.0001). Overall, HPV 58 and 54 were the most predominant high-risk (18.8%) and
low-risk (15.0%) genotypes detected. The two most common hr-HPV genotype isolates were 58
(18.8%) and 35 (15.9%) with 58 being the most prevalent among age group 35–44 years compared
with hr-HPV 16, 18, 35 and 45, found predominantly among 18–34 age group.
conclusions Significant variations exist in HPV genotypes among HIV-infected and uninfected
women.
Description
This article is published by Tropical Medicine and International Health and is also available at https://doi.org/10.1111/tmi.12645
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Citation
volume 21 no 2 pp 275–282 february 2016