he genomic epidemiology of multi drug resistant invasive non-typhoidal Salmonella in selected sub-Saharan African countries
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Date
2021
Journal Title
Journal ISSN
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Publisher
BMJ GLOBAL HEALTH
Abstract
Background Invasive non-typhoidal Salmonella (iNTS) is
one of the leading causes of bacteraemia in sub-Saharan
Africa. We aimed to provide a better understanding of
the genetic characteristics and transmission patterns
associated with multi-drug resistant (MDR) iNTS serovars
across the continent.
Methods A total of 166 iNTS isolates collected from
a multi-centre surveillance in 10 African countries
(2010–2014) and a fever study in Ghana (2007–2009)
were genome sequenced to investigate the geographical
distribution, antimicrobial genetic determinants and
population structure of iNTS serotypes–genotypes.
Phylogenetic analyses were conducted in the context of the
existing genomic frameworks for various iNTS serovars.
Population-based incidence of MDR-iNTS disease was
estimated in each study site.
Results Salmonella Typhimurium sequence-type (ST) 313
and Salmonella Enteritidis ST11 were predominant, and both
exhibited high frequencies of MDR; Salmonella Dublin ST10
was identified in West Africa only. Mutations in the gyrA gene
(fluoroquinolone resistance) were identified in S. Enteritidis
and S. Typhimurium in Ghana; an ST313 isolate carrying
blaCTX-M-15 was found in Kenya. International transmission
of MDR ST313 (lineage II) and MDR ST11 (West African
clade) was observed between Ghana and neighbouring
West African countries. The incidence of MDR-iNTS disease
exceeded 100/100 000 person-years-of-observation in
children aged <5 years in several West African countries
Description
This article is published by BMJ Global Health and is also available at http://gh.bmj.com/
Keywords
Citation
Park SE, Pham DT, Pak GD, et al. The genomic epidemiology of multi-drug resistant invasive non typhoidal Salmonella in selected sub-Saharan African countries.