Sero-epidemiology of human coronaviruses in three rural communities in Ghana

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dc.contributor.authorOwusu, Michael
dc.contributor.authorSylverken, Augustina Angelina
dc.contributor.authorEl-Duah, Philip
dc.contributor.authorAcheampong, Godfred
dc.contributor.authorMutocheluh,, Mohammed
dc.contributor.authorAdu-Sarkodie, Yaw
dc.contributor.orcid0000-0001-5066-150X
dc.contributor.orcid0000-0002-7691-914X
dc.contributor.orcid0000-0003-1671-0755
dc.contributor.orcid0000-0003-2495-9235
dc.contributor.orcid0000-0002-1396-5085
dc.contributor.orcid0000-0003-2093-1534
dc.date.accessioned2024-02-21T12:43:10Z
dc.date.available2024-02-21T12:43:10Z
dc.date.issued2021
dc.descriptionThis is an article published by Michael Owusu et al. Sero-epidemiology of human coronaviruses in three rural communities in Ghana. Pan African Medical Journal. 2021;38(244). 10.11604/pamj.2021.38.244.26110 Available online at: https://www.panafrican-med-journal.com//content/article/38/244/full
dc.description.abstractIntroduction: acute respiratory tract infections (ARIs) are responsible for significant proportions of illnesses and deaths annually. Most of ARIs are of viral etiology, with human coronaviruses (HCoVs) playing a key role. This study was conducted prior to the outbreak of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) to provide evidence about the sero-epidemiology of HCoVs in rural areas of Ghana. Methods: this was a cross sectional study conducted as part of a large epidemiological study investigating the occurrence of respiratory viruses in 3 rural areas of Ghana; Buoyem, Kwamang and Forikrom. Serum samples were collected and tested for the presence of IgGantibodies to three HCoVs; HCoV-229E, HCoV OC43 and HCoV-NL63 using immunofluorescence assay. Results: of 201 subjects enrolled into the study, 97 (48.3%) were positive for all three viruses. The most prevalent virus was HCoV-229E (23%; 95% CI: 17.2 - 29.3), followed by HCoV-OC43 (17%; 95% CI: 12.4 - 23.4), then HCoV-NL63 (8%, 95% CI: 4.6 - 12.6). Subjects in Kwamang had the highest sero-prevalence for HCoV-NL63 (68.8%). human coronaviruses-229E (41.3%) and HCoV-OC43 (45.7%) were much higher in Forikrom compared to the other study areas. There was however no statistical difference between place of origin and HCoVs positivity. Although blood group O+ and B+ were most common among the recruited subjects, there was no significant association (p = 0.163) between blood group and HCoV infection. Conclusion: this study reports a 48.3% sero-prevalence of HCoVs (OC43, NL63 and 229E) among rural communities in Ghana. The findings provide useful baseline data that could inform further sero-epidemiological studies on SARS-CoV-2 in Africa.
dc.description.sponsorshipKNUST
dc.identifier.citationMichael Owusu et al. Sero-epidemiology of human coronaviruses in three rural communities in Ghana. Pan African Medical Journal. 2021;38(244). 10.11604/pamj.2021.38.244.26110; Available online at: https://www.panafrican-med-journal.com//content/article/38/244/full
dc.identifier.urihttps://www.panafrican-med-journal.com//content/article/38/244/full
dc.identifier.urihttps://ir.knust.edu.gh/handle/123456789/15526
dc.language.isoen
dc.publisherPan African Medical Journal
dc.titleSero-epidemiology of human coronaviruses in three rural communities in Ghana
dc.typeArticle
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