Acalyphawilkesiana ‘inferno’hydroethanolicleafextracthas protectiveeffectoncarbontetrachloride-inducedsubacute toxicityinanimals

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dc.contributor.authorLarbie, Christopher
dc.contributor.authorEmikpe, Benjamin O.
dc.contributor.authorOyagbemi, Ademola A.
dc.contributor.authorNyarko, Ruby A.
dc.contributor.authorJarikre, Theophilus A.
dc.contributor.authorAdjei, Clement O.
dc.contributor.authorAseidu, Emmanue lB.
dc.date.accessioned2020-09-28T11:48:16Z
dc.date.accessioned2023-04-19T02:14:16Z
dc.date.available2020-09-28T11:48:16Z
dc.date.available2023-04-19T02:14:16Z
dc.date.issued2020-05
dc.descriptionThis article is published in Biomedical Research and Therapy and also available at DOI : 10.15419/bmrat.v7i5.605en_US
dc.description.abstractIntroduction: Liverfibrosisisoneofthemostcommonclinicalmanifestationsofhepaticdiseases. However, though many synthetic drugs exist for the treatment and prevention of liver diseases, liver injuries still persist. The present study, therefore, sought to investigate the subacute protective effects of Acalphyawilkesiana against carbon tetrachloride (CCl4)-induced toxicity in animals. Methodology: Liver injury was induced in experimental animals by administering CCl4 (1:1 v/v in olive oil, intraperitoneally (i.p.), twice weekly for 8 weeks) after pre-treatment with extract of A. wilkesiana(AWE).AWE(250mg/kg)andSilymarin(120mg/kg)wereadministeredorally(dailyfor8 weeks). Thehepatoprotectiveeffectwasstudiedbyassayingtheactivityofliverenzymes,suchas alanineaminotransferase(ALT),aspartateaminotransferase(AST),alkalinephosphatase(ALP),and alpha-fetoprotein. Theeffectofthetreatmentsonliverprooxidants(e.g. malondialdehyde[MDA]) andantioxidants(e.g. superoxidedismutase[SOD],reducedglutathione[GSH],glutathioneperoxidase [GPx], and glutathione transferase [GST]), as well as inflammatory cytokines (e.g. interleukin [IL]-17, IL-23, nuclear factor kappa beta [NF-kB], and cycloxygenase-1 [COX-1]) and the histology of the liver were also examined. Results: The activity of liver function biomarkers changed significantly upon CCl4 administration; increases in ALT, total and direct bilirubin, and some fibrosis indices (e.g. alpha-fetoprotein and APRI [p<0.05-0.001, compared with normal]) were observed. Co-administration of AWE with CCl4 restored these to normal levels. The intensity of structural alterations revealed that the AWE treatment has protective potential against subacute liver injury. AWEtreatmentalsoreducedtheexpressionofIL-17,1L-23,NF-kBandCOX-1,underscoringitsantiinflammatory properties. Conclusion: The results of the current study generally suggest that hydroethanolicleafextractsofA.wilkesianainfernopossesssomesubacuteprotectiveactivitybyimproving liver function and inhibition of inflammation, and could be developed as a potent antifibroticagent.en_US
dc.description.sponsorshipKNUSTen_US
dc.identifier.citationBiomedical Research and Therapy, 7(5):3778-3788en_US
dc.identifier.uri10.15419/bmrat.v7i5.605
dc.identifier.urihttps://ir.knust.edu.gh/handle/123456789/13099
dc.language.isoenen_US
dc.publisherBiomedical Research and Therapyen_US
dc.subjectAcalyphawilkesianainfernoen_US
dc.subjectcarbontetrachlorideen_US
dc.subjecthepatoprotectiveeffecten_US
dc.subjectmedicinal plantsen_US
dc.subjectinterleukinsen_US
dc.titleAcalyphawilkesiana ‘inferno’hydroethanolicleafextracthas protectiveeffectoncarbontetrachloride-inducedsubacute toxicityinanimalsen_US
dc.typeArticleen_US
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