Hepatoprotective Potential of Hura crepitans L.: A Review of Ethnomedical, Phytochemical and Pharmacological Studies

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dc.contributor.authorOwojuyigbe, Oluwole S.
dc.contributor.authorFirempong, Caleb K.
dc.contributor.authorLarbie, Christopher
dc.contributor.authorKomlaga, Gustav
dc.contributor.authorEmikpe, Benjamin O.
dc.date.accessioned2020-09-28T15:13:34Z
dc.date.accessioned2023-04-19T02:16:31Z
dc.date.available2020-09-28T15:13:34Z
dc.date.available2023-04-19T02:16:31Z
dc.date.issued2020-03
dc.descriptionThis article is published in Journal of Complementary and Alternative Medical Research and also available at 10.9734/JOCAMR/2020/v9i230136en_US
dc.description.abstractHerbal medicines are the main source of treatment of diseases in non-urban centres of the developing world. Secondary metabolites obtained from herbal sources contain bioactive phytochemicals, many of which have been the origin for the development of novel pharmaceutical drugs. Hura crepitans L. (Euphorbiaceae) or sandbox tree has been beneficial in many ethnomedicinal applications as a purgative, emetic, hepatoprotective, anti-inflammatory, antimicrobial and the treatment of leprosy. Toxicological, phytochemical and bactericidal studies have also been documented. This paper reviews the potential of the Hura crepitans plant in protecting the liver against drug-induced toxicity. The paper dwells extensively on the ethnomedical, phytochemical and pharmacological properties of the plant. In achieving the above, intensive analyses of books and published peer-reviewed journal articles were carried out using credible scientific databases. Four main phytochemicals were revealed to be contained in Hura crepitans stem-bark. Their protective effects were enunciated using animal models. However much more biochemical studies need to be done to establish the hepatoprotective potentials of the various parts and various phytochemicals of Hura crepitans with the need for more preclinical and clinical studies. We, therefore, present in this paper efforts to elucidate and bring to the fore the therapeutic potentials of Hura crepitans plant.en_US
dc.description.sponsorshipKNUSTen_US
dc.identifier.citationJournal of Complementary and Alternative Medical Research, 9(2): 1-10,en_US
dc.identifier.uri10.9734/JOCAMR/2020/v9i230136
dc.identifier.urihttps://ir.knust.edu.gh/handle/123456789/13113
dc.language.isoenen_US
dc.publisherJournal of Complementary and Alternative Medical Researchen_US
dc.subjectHura crepitans L.en_US
dc.subjecttoxicological assessmenten_US
dc.subject; phytochemical propertiesen_US
dc.subject; hepato-protectionen_US
dc.titleHepatoprotective Potential of Hura crepitans L.: A Review of Ethnomedical, Phytochemical and Pharmacological Studiesen_US
dc.typeArticleen_US
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