Hydroethanolic Extracts of Ficus pumila Linn. Is Protective against Gentamicin-Induced Kidney Damage in Rats

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dc.contributor.authorLarbie, Christopher
dc.contributor.authorSiaw, Portia A
dc.contributor.authorZon, Solomon
dc.contributor.authorAppiah-Kubi, Kwame
dc.date.accessioned2020-09-28T15:25:03Z
dc.date.accessioned2023-04-19T02:16:44Z
dc.date.available2020-09-28T15:25:03Z
dc.date.available2023-04-19T02:16:44Z
dc.date.issued2018-06
dc.descriptionThis article is published in Journal of Advances in Medical and Pharmaceutical Sciences and also available at 10.9734/JAMPS/2018/41291en_US
dc.description.abstractN(3%1(2 Linn. has been reported to be rich in phenols, hepatoprotective and antiproliferative on leukemic cancer cells. The aim of this study was to evaluate the nephroprotective effect of hydroethanolic leaves extracts of N5%1(2 on gentamicin-induced kidney damage in rats. Twentyseven female Wistar albino rats were divided into 9 groups (n=3). Group 1 being normal; group 2 was the gentamicin (GM) induced only (80 mg/kg b/w ip for 5 days); groups 3, 4, & 5 rats were treated with gentamicin (80mg/kg b/w ip for 5 days) and N5%1(2 extract at 100, 250, and 500 mg/kg b/w orally respectively; groups 6, 7 & 8 rats received the extract only (100, 250, and 500 mg/kg b/w orally) respectively and group 9 being gentamicin and silymarin (100 mg/kg b/w orally) for 21 days. Blood samples were taken 24 hrs after the experimented period and biochemical and haematological parameters were analyzed. GM nephrotoxicity was characterized by significantly increased levels of serum creatinine, urea, sodium, potassium and WBC, while reduced RBC, HGB, MCH and MCV levels compared with normal group. Rats treated with gentamicin and the extract showed a significant reduction in the levels of these markers. The results suggest that hydroethanolic extract of N(3%1(2 leaves protect against gentamicin-induced nephrotoxicity in female Wistar albino rats.en_US
dc.description.sponsorshipKNUSTen_US
dc.identifier.citationJournal of Advances in Medical and Pharmaceutical Sciences ,17(2): 1-8en_US
dc.identifier.uri10.9734/JAMPS/2018/41291
dc.identifier.urihttps://ir.knust.edu.gh/handle/123456789/13114
dc.language.isoenen_US
dc.publisherJournal of Advances in Medical and Pharmaceutical Sciencesen_US
dc.titleHydroethanolic Extracts of Ficus pumila Linn. Is Protective against Gentamicin-Induced Kidney Damage in Ratsen_US
dc.typeArticleen_US
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