Stroke in Indigenous Africans, African Americans, and European Americans Interplay of Racial and Geographic Factors

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dc.contributor.authorOwolabi, Mayowa
dc.contributor.authorSarfo, Fred Stephen
dc.contributor.authorHoward, Virginia J.
dc.contributor.authorIrvin, Marguerite R.
dc.contributor.authorGebregziabher, Mulugeta
dc.contributor.authorAkinyemi, Rufus
dc.contributor.authorBennett, Aleena
dc.contributor.authorArmstrong, Kevin
dc.contributor.authorTiwari, Hemant K.
dc.contributor.authorAkpalu, Albert...et.al.
dc.date.accessioned2021-02-24T10:37:26Z
dc.date.accessioned2023-04-19T02:46:19Z
dc.date.available2021-02-24T10:37:26Z
dc.date.available2023-04-19T02:46:19Z
dc.date.issued2017
dc.descriptionAn article published in Stroke. 2017;48:1169-1175. DOI: 10.1161/STROKEAHA.116.015937en_US
dc.description.abstractBackground and Purpose—The relative contributions of racial and geographic factors to higher risk of stroke in people of African ancestry have not been unraveled. We compared stroke type and contributions of vascular risk factors among indigenous Africans (IA), African Americans (AA), and European Americans (EA). Methods—SIREN (Stroke Investigative Research and Educational Network) is a large multinational case–control study in West Africa—the ancestral home of 71% AA—whereas REGARDS (Reasons for Geographic and Racial Differences in Stroke) is a cohort study including AA and EA in the United States. Using harmonized assessments and standard definitions, we compared data on stroke type and established risk factors for stroke in acute stroke cases aged ≥55 years in both studies. Results—There were 811 IA, 452 AA, and 665 EA stroke subjects, with mean age of 68.0±9.3, 73.0±8.3, and 76.0±8.3 years, respectively (P<0.0001). Hemorrhagic stroke was more frequent among IA (27%) compared with AA (8%) and EA (5.4%; P<0.001). Lacunar strokes were more prevalent in IA (47.1%), followed by AA (35.1%) and then EA (21.0%; P<0.0001). The frequency of hypertension in decreasing order was IA (92.8%), followed by AA (82.5%) and then EA (64.2%; P<0.0001) and similarly for diabetes mellitus IA (38.3%), AA (36.8%), and EA (21.0%; P<0.0001). Premorbid sedentary lifestyle was similar in AA (37.7%) and EA (34.0%) but lower frequency in IA (8.0%). Conclusions—Environmental risk factors such as sedentary lifestyle may contribute to the higher proportion of ischemic stroke in AA compared with IA, whereas racial factors may contribute to the higher proportion of hypertension and diabetes mellitus among stroke subjects of African ancestry.en_US
dc.description.sponsorshipKNUSTen_US
dc.identifier.citationStroke. 2017;48:1169-1175. DOI: 10.1161/STROKEAHA.116.015937en_US
dc.identifier.urihttps://ir.knust.edu.gh/handle/123456789/13441
dc.language.isoenen_US
dc.publisherStrokeen_US
dc.subjectCase–control studyen_US
dc.subjectCohort studyen_US
dc.subjectDeathen_US
dc.subjectRisk factorsen_US
dc.subjectStrokeen_US
dc.titleStroke in Indigenous Africans, African Americans, and European Americans Interplay of Racial and Geographic Factorsen_US
dc.typeArticleen_US
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