Human defensins and Th-1 cytokines in hepatitis C viral infection

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dc.contributor.authorOwusu, Dorcas Ohui
dc.contributor.authorOwusu, Michael
dc.contributor.authorOwusu, Bright Afriyie
dc.contributor.orcid0000-0003-4299-5870
dc.contributor.orcid0000-0001-5066-150X
dc.date.accessioned2024-02-21T12:21:45Z
dc.date.available2024-02-21T12:21:45Z
dc.date.issued2020
dc.descriptionThis is an article published by Dorcas Ohui Owusu et al. Human defensins and Th-1 cytokines in hepatitis C viral infection. Pan African Medical Journal. 2020;37(103). 10.11604/pamj.2020.37.103.25211 Available online at: https://www.panafrican-med-journal.com//content/article/37/103/full
dc.description.abstractIntroduction: active or chronic exacerbated forms of hepatitis C virus (HCV) infection subsequently progress to liver disease and human defensins has been determined to have some level of anti-viral properties invitro whilst the expression of T helper-1 cytokines is known to promote complete recovery from acute HCV infection. The study sought to determine relationship between these immune responses. Methods: a cross sectional descriptive study design was employed. Hundred and thirty-two individuals were assessed were assessed for to anti-HCV, HCV RNA, serum levels of human alpha defensins 1 (HAD-1) and human beta defensins 1 (HBD-1). T helper 1 cytokines (IL-2, IFN gamma, TNF alpha) secreted in serum were also analyzed using commercial ELISA assay. The study was conducted in Kumasi, Obuasi and Daboya in Ghana. Results: the serum mean concentrations of HAD-1, HBD-1, IL-2, IFN gamma and TNF alpha showed no significant difference in concentrations among participants with chronic, spontaneously recovered or negative to HCV infection (p>0.05). Persons with hepatitis B co-infection were more likely to develop chronic HCV infection (p=0.039). HAD-1 and HBD-1 showed significant positive association with IL-2 (p=0.000) whilst only HAD-1 positively correlated with IL-2 (p<0.000). Conclusion: the immunological markers determined had no association with the status of HCV infection. HAD-1 increased with increasing levels of IL-2. These findings suggest that during HCV infection, inflammatory response through the production of cytokines by IL-2 cells may affect the release of HAD-1 and HBD-1.
dc.description.sponsorshipKNUST
dc.identifier.citationDorcas Ohui Owusu et al. Human defensins and Th-1 cytokines in hepatitis C viral infection. Pan African Medical Journal. 2020;37(103). 10.11604/pamj.2020.37.103.25211 Available online at: https://www.panafrican-med-journal.com//content/article/37/103/full
dc.identifier.urihttps://www.panafrican-med-journal.com//content/article/37/103/full
dc.identifier.urihttps://ir.knust.edu.gh/handle/123456789/15524
dc.language.isoen
dc.publisherPan African Medical Journal
dc.titleHuman defensins and Th-1 cytokines in hepatitis C viral infection
dc.typeArticle
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