Browsing by Author "Yorke, Joseph"

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    Association of genetic variants with prostate cancer in Africa: a concise review
    (Springer Open, 2021) Acheampong, Emmanuel; Asamoah Adu, Evans; Obirikorang, Christian; Amoah, George; Afriyie, Osei Owusu; Yorke, Joseph; Odame Anto, Enoch; Adu Gyamfi, Michael; 0000-0002-5229-0340
    Background: Prostate cancer (PCa) has one of the highest heritability of all major cancers, where the genetic contribution has been documented, and knowledge about the molecular genetics of the disease is increasing. However, the extent and aspects to which genetic variants explain PCa heritability in Africa are limited. Main body: In this review, we summarize studies that highlight how identified genetic variants explain differences in PCa incidence and presentation across ethnic groups. We also present the knowledge gaps in PCa genetics in Africa and why Africa represents an untapped potential ground for genetic studies on PCa. A significant number of genome-wide association studies, linkage, and fine-mapping analyses have been conducted globally, and that explains 30–33% of PCa heritability. The African ancestry has a significant mention in PCa incidence and presentation. To date, the candidate gene approach has replicated 23 polymorphisms including dinucleotide and trinucleotide repeats in 16 genes. CYP17-rs743572, CYP3A4-rs2740574, CYP3A5-rs776746, CYP3A43-rs501275, and haplotype blocks, containing these variants, are significantly associated with PCa among some population groups but not others. With the few existing studies, the extent of genetic diversity in Africa suggests that genetic associations of PCa to African ancestry go beyond nucleotide sequence polymorphisms, to a level of environmental adaptation, which may interpret genetic risk profiles. Also, the shreds of evidence suggest that evolutionary history contributes to the high rates of PCa relative to African ancestry, and genetic associations do not always replicate across populations. Conclusion: The genetic architecture of PCa in Africa provides important contributions to the global understanding of PCa specifically the African-ancestry hypothesis. There is a need for more prostate cancer consortiums to justify the heritable certainties of PCa among Africans, and emphasis should be placed on the genetic epidemiological model of PCa in Africa.
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    Height and sex estimation using percutaneous humeral length among Ghanaians
    (Elsevier, 2024) Tetteh, Joshua; Diby, Thomas; Abaidoo, Chrissie Stansie; Yorke, Joseph; Robertson, Juliet; Nketsiah, James; 0000-0002-5229-0340
    Introduction: Humerus is a long bone that contributes significantly to the total height of an individual. It is sexually dimorphic and is a well-preserved bone postmortem. Height and sex are essential in establishing one’s identity and can be estimated from long bones when standing height cannot be easily obtained. Previous studies report that sex and height are population-specific. Hence, the present study sought to establish the relationship between percutaneous humeral lengths and height and formulate models for height and sex determination for the Ghanaian population. Materials and methods: Measurement of standing height and percutaneous humeral lengths were taken from 286 Ghanaian consented participants with no noticeable lower and upper extremities traumas or pathologies. The data was analysed using Microsoft Excel 2013 and SPSS version 23.0 edition. Correlation analysis was done to determine the correlation of the percutaneous humeral length with height, linear regression and binary logistic analyses were used to derive equations for predicting height and sex from percutaneous humeral length. An independent samples t-test was used to determine the means between males and females, left and right percu taneous humeral lengths. Results: There was a strong positive correlation between standing height and left (r = 0.774) and right (r=0.759) humeral lengths. The left humeral length regression equation was a good height estimator in males (75.4%) and females (71.%). The left and right humeral lengths best predicted the sex for the population, with an accuracy of 78.0% and 77.8% for males and 53.8% and 54.6% for females, respectively. Conclusion: This study has added to the limited data on the use of percutaneous humeral length as a substitute for the determination of standing height and sex in the Ghanaian population, and it is also a significant identification tool which can be employed in the field of forensic anthropometry.