Browsing by Author "Dapaah, Sylvester Samuel"

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    Estimated dietary exposure to veterinary residues in chicken and eggs
    (International Journal of Food Contamination, 2015) Darko, Godfred; Mensah, John Kenneth; Dapaah, Sylvester Samuel; Odei, Judith; 0000-0001-7157-646X
    Background: Chicken tissues and eggs were analyzed for residues of eight veterinary drugs including albendazole, piperazine, tiamulin, chloramphenicol, levamisole, sulphathiazole, sulphamethoxazole and oxytetracycline oxytetracycline. Results: Mean residue concentrations of all drugs varied by tissue and ranged from 0.004 μg/kg for tiamulin in eggs to 8.6 μg/kg for chloramphenicol in liver. Total residues of all drugs in the liver generally exceeded that of the kidney, muscles and eggs by at least a two-fold difference. The general order of decreasing total drug residue levels is liver > kidney > muscle > eggs. The exposure due to albendazole and sulphamethoxazole in liver were 2- and 7-folds higher than their recommended average daily intake. Exposure due to piperazine, sulphamethoxazole, levamisole and tiamulin were, however, lower than their respective recommended limits. Conclusion: Dietary exposure assessments of all drugs based on quantitated residue levels are within the Joint FAO/ WHO Expert Committee on Food Additives safe regulatory exposure limits. This study informs the public about veterinary drug residues in poultry and helps address policy and regulatory changes in the use of veterinary drugs in poultry.
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    Veterinary drug residues in chicken parts from five selected poultry farms in the Kumasi Metropolitan, Offinso-South Municipality and Kwabre-East District of Ashanti Region- Ghana
    (2014) Dapaah, Sylvester Samuel
    Samples of liver, kidney and muscles of chicken from three different Districts in Ashanti-region of Ghana were analyzed for veterinary drug residues (including albendazole, piperazine, tiamulin, chloramphenicol, levamisole, sulphathiazine, sulphamethoxazole and oxy-tetracycline) with HPLC equipped with photodiode array (PDA) detector. Homogenized samples were extracted using acetonitrile and cleanup on C-18 solid phase column.The average recoveries of the drug residues in veterinary drugs in chicken parts were in the range of 76.0-98.8%. The limit of detection was 0.01 μg/kg and the limit of quantification was 0.03 μg/kg for all the compounds. Offinso-South Municipality recorded the highest mean concentration of 1542.0±62.73 μg/kg drug residues and was closely followed by residues in liver samples from Kentinkrono (1424.0±49.82 μg/kg). Samples from Kwabre District showed the least level of accumulation (1328.0±16.68 μg/kg) residues in the liver and this was very close to the kidney residue accumulation in the same District. Kwabre District however recorded the highest concentrations of residues (1247.0±42.39 μg/kg) in the kidney followed by Offinso municipality. Kentinkrono had the least accumulation of veterinary drug residue in the kidney. The concentrations of residue in the muscles from all the five farms visited were insignificantly different (p ˂ 0.05). Offinso recorded the highest accumulation of 390.0±40.97 μg/kg closely followed by Kwabre, 374.8±47.11 μg/kg. Kentinkrono registered the lowest concentration of 343.7±35.85 μg/kg. Residues of all veterinary drugs were higher in liver and/or kidney tissue as compared tomuscle tissue. Liver parts registered the highest mean concentration (1455.0±85.7 μg/kg) followed by kidney parts which registered 887.5±45.8 μg/kg mean concentration. Muscle parts registered the lowest concentration (371.2±33.6) in all the farms. Levamisole present in the meat may pose risk to the consumers as their mean concentrations mostly exceeded the recommended JECFA MRLs. Chloramphenicol recorded highest global estimated chronic dietary exposure of 1.018 μg/kg body weight per day whiles albendazole and sulphathiazine registered 0.306 μg/kg body weight per day and 0.313 μg/kg body weight per day respectively. Chloramphenicol and levamisole were detected in all the samples. These chemicals that exceeded the recommended limits may pose health risk to the consuming public. Keywords: Poultry, veterinary drugs, residues, albendazole, piperazine, tiamulin, chloramphenicol, levamisole, sulphathiazine, sulphamethoxazole and oxy-tetracycline.