Browsing by Author "Ampadu, Edwin"

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    Clinical Efficacy of Combination of Rifampin and Streptomycin for Treatment of Mycobacterium ulcerans Disease
    (Antimicrobial Agents and Chemotherapy, 2010-09) Sarfo, Fred Stephen; Phillips, Richard Odame; Asiedu, Kingsley; Ampadu, Edwin; Bobi, Nana; et.al
    We have evaluated the clinical efficacy of the combination of oral rifampin at 10 mg/kg of body weight and intramuscular streptomycin at 15 mg/kg for 8 weeks (RS8), as recommended by the WHO, in 160 PCRconfirmed cases of Mycobacterium ulcerans disease. In 152 patients (95%) with all forms of disease from early nodules to large ulcers, with or without edema, the lesions healed without recourse to surgery. Eight patients whose ulcers were healing poorly had skin grafting after completion of antibiotics. There were no recurrences among 158 patients reviewed at the 1-year follow-up. The times to complete healing ranged from 2 to 48 weeks, according to the type and size of the lesion, but the average rate of healing (rate of reduction in ulcer diameter) varied widely. Thirteen subjects had positive cultures for M. ulcerans during or after treatment, but all the lesions healed without further antibiotic treatment. Adverse events were rare. These results confirm the efficacy of RS8 delivered in a community setting.
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    Reply to “Compliance with Antimicrobial Therapy for Buruli Ulcer”
    (Antimicrobial Agents and Chemotherapy, 2014-10) Phillips, Richard Odame; Sarfo, Fred Stephen; Abass, Mohammed K.; Frimpong, Michael; Ampadu, Edwin; et. al
    Recently, Klis et al. conducted an audit of Buruli ulcer case record forms of patients managed under routine care conditions in a Buruli ulcer treatment center and showed a surprisingly high rate (54%) of noncompliance with therapy (1). Incomplete adherence to treatment has been identified as the most serious problem in tuberculosis control (2) and a major obstacle to the elimination of the disease (3). To ensure adherence to therapy in our study, several approaches were incorporated into patient care. These included issuing medication in 2-weekly batches, allowing the clinician several opportunities to assess adherence during therapy.