Browsing by Author "Afutu, Rhoda"

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    Mathematical modelling of the transmission dynamics of Marburg virus disease with optimal control and cost-effectiveness analysis based on lessons from Ebola virus disease
    (Springer, 2024) Reindorf, Nartey Borkor; Amoah-Mensah, John; Opoku, Nicholas Kwasi-Do Ohene; Boateng, Francis Ohene; Bonsu, Kwame; Afosaa, Vida; Afutu, Rhoda; 0000-0002-5721-4638
    Marburg virus, like Ebola, causes haemorrhagic disease with high fatality rates. We developed a deterministic SEIRDVT model incorporating vaccination and treatment to study the disease dynamics. Qualitative analysis revealed a backward bifurcation when R0 = 1, meaning R0 < 1 is insufficient to eradicate the virus. Sensitivity analysis using Latin Hypercube Sampling showed that applying four control measures—screening, prevention, continuous vaccination, and treatment—significantly reduced transmission. The most cost-effective strategy combines prevention, vaccination, and treatment. These findings provide a framework for designing efficient interventions to combat Marburg virus.