Aqueous ethanolic extract of Acalypha inferno accelerates the clearance of glucose in normoglycaemic rats

Simple item page
dc.contributor.authorLarbie, Christopher
dc.contributor.authorOduro, Juliana
dc.contributor.authorTofah, Jesse John
dc.date.accessioned2020-09-28T12:07:37Z
dc.date.accessioned2023-04-19T02:14:29Z
dc.date.available2020-09-28T12:07:37Z
dc.date.available2023-04-19T02:14:29Z
dc.date.issued2018-01
dc.descriptionThis article is published by The Pharma Innovation Journal and also available at www.thepharmajournal.comen_US
dc.description.abstractGlucose tolerance refers to the body’s ability to metabolise glucose within a stipulated time interval. Failure of the body to use glucose results in hyperglycaemia and progressively to diabetes. Acalypha inferno (family Euphorbiaceae) is an ornamental plant found widely in the tropics of Africa and known for its phytoremediating properties. The study was aimed at investigating the effects of aqueous ethanolic extract of Acalypha inferno on oral glucose tolerance in normoglycaemic rats. A 50% hydro-ethanolic extract of the leaves was prepared, and the oral glucose tolerance effect of the plant assessed for 14 days in normoglycaemic rats at doses of 100mg, 250mg and 500mg/kg body weight. Glibenclamide (10mg/kg) was used as a standard drug. The effect of treatment on body weight, OGTT at day 7 and 14, lipid profile and kidney function were assessed. On day 7, FBG level increased from 4.93±0.29mmol/l to 25.03±0.93mmol/l after 1 hour and 17.53±4.50mmol/l after 3 hours in normal group. Extract and drug treated groups prevented such increases at all doses (p<0.001). FBG levels were restored to basal levels after 8 hours. Total cholesterol increased in the 250 mg group with a significant increase in LDL levels in the 100mg, 250mg and 500mg group compared to the normal. There was no significant difference in relative kidney weight, urea and creatinine levels. The hydro-ethanolic extract of Acalypha inferno possesses glucose tolerance abilities in normoglycaemic rats.en_US
dc.description.sponsorshipKNUSTen_US
dc.identifier.citationThe Pharma Innovation Journal, 7(2): 79-83en_US
dc.identifier.issn2277- 7695
dc.identifier.issn2349-8242
dc.identifier.urihttps://ir.knust.edu.gh/handle/123456789/13102
dc.language.isoenen_US
dc.publisherThe Pharma Innovation Journalen_US
dc.subject: Oral glucose toleranceen_US
dc.subjectAcalypha infernoen_US
dc.subjectNormo-glycaemic ratsen_US
dc.subjectHyperglycaemiaen_US
dc.titleAqueous ethanolic extract of Acalypha inferno accelerates the clearance of glucose in normoglycaemic ratsen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Aqueous ethanolic extract of Acalypha inferno accelerates the clearance of glucose in normoglycaemic rats.pdf
Size:
587.51 KB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 2 of 2
Thumbnail Image
Name:
license.txt
Size:
1.73 KB
Format:
Item-specific license agreed to upon submission
Description:
Download
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed to upon submission
Description:
Download
Collections
Articles