Dynamics of T-cell IFN-γ and miR-29a expression during active pulmonary tuberculosis
dc.contributor.author | Awuah Afum-Adjei Anthony | |
dc.contributor.author | Ueberberg Bianca | |
dc.contributor.author | Owusu-Dabo Ellis | |
dc.contributor.author | Frempong Margaret | |
dc.contributor.author | Jacobsen Marc | |
dc.date.accessioned | 2023-12-06T14:33:39Z | |
dc.date.available | 2023-12-06T14:33:39Z | |
dc.date.issued | 2014 | |
dc.description | This article is published by International Immunology and is also available at https://doi.org/10.1093/intimm/dxu068 | |
dc.description.abstract | IFN-γ is crucial for protection against Mycobacterium tuberculosis. miR-29 was recently shown to non-redundantly inhibit IFN-γ. Here, we investigated IFN-γ and miR-29a expression dynamics of CD4+ T cells from patients during active tuberculosis (TB) (n = 32) and in household contacts who were latently M. tuberculosis infected (n = 19) from Ghana. Whereas M. tuberculosis-specific IFN γ expression was similar during TB chemotherapy, superantigen stimulation indicated generally impaired IFN-γ expression in TB patients. No interdependency between miR-29a and IFN-γ expression of T cells was observed. However, miR-29a was differentially expressed in T cells during chemotherapy. We concluded that differential miR-29a expression in active TB was not causative for impaired IFN-γ expression. | |
dc.description.sponsorship | KNUST | |
dc.identifier.citation | International Immunology, Vol. 26, No. 10, pp. 579–582 doi:10.1093/intimm/dxu068 Advance Access publication 30 June 2014 | |
dc.identifier.uri | 10.1093/intimm/dxu068 | |
dc.identifier.uri | https://ir.knust.edu.gh/handle/123456789/14674 | |
dc.language.iso | en | |
dc.publisher | International Immunology | |
dc.title | Dynamics of T-cell IFN-γ and miR-29a expression during active pulmonary tuberculosis | |
dc.type | Article |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- Dynamics of T-cell IFN-γ and miR-29a expression.pdf
- Size:
- 328.26 KB
- Format:
- Adobe Portable Document Format
- Description:
License bundle
1 - 1 of 1
Loading...
- Name:
- license.txt
- Size:
- 1.71 KB
- Format:
- Item-specific license agreed to upon submission
- Description: