Cytotoxic T Cell-Derived Granzyme B Is Increased in Severe Plasmodium Falciparum Malaria

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dc.contributor.authorKaminski Lea-Christina
dc.contributor.authorRiehn Mathias
dc.contributor.authorOwusu-Dabo Ellis
dc.contributor.authorAbel Annemieke
dc.contributor.authorSteeg Christiane....et al
dc.contributor.orcid0000-0003-4232-4292
dc.date.accessioned2023-12-13T16:14:45Z
dc.date.available2023-12-13T16:14:45Z
dc.date.issued2019
dc.descriptionThis article is published by Frontiers in Immunology and is also at https://doi.org/10.3389/fimmu.2019.02917ailable at
dc.description.abstractIn Plasmodium falciparum malaria, CD8+ T cells play a double-edged role. Liver-stage specific CD8+ T cells can confer protection, as has been shown in several vaccine studies. Blood-stage specific CD8+ T cells, on the other hand, contribute to the development of cerebral malaria in murine models of malaria. The role of CD8+ T cells in humans during the blood-stage of P. falciparum remains unclear. As part of a cross-sectional malaria study in Ghana, granzyme B levels and CD8+ T cells phenotypes were compared in the peripheral blood of children with complicated malaria, uncomplicated malaria, afebrile but asymptomatically infected children and non-infected children. Granzyme B levels in the plasma were significantly higher in children with febrile malaria than in afebrile children. CD8+ T cells were the main T cell subset expressing granzyme B. The proportion of granzyme B+ CD8+ T cells was significantly higher in children with complicated malaria than in uncomplicated malaria, whereas the activation marker CD38 on CD8+ T cells showed similar expression levels. This suggests a pathogenic role of cytotoxic CD8+ T cells in the development of malaria complications in humans.
dc.description.sponsorshipKNUST
dc.identifier.citationFront. Immunol., 11 December 2019 Sec. Microbial Immunology Volume 10 - 2019 | https://doi.org/10.3389/fimmu.2019.02917
dc.identifier.uri10.3389/fimmu.2019.02917
dc.identifier.urihttps://ir.knust.edu.gh/handle/123456789/14839
dc.language.isoen
dc.publisherFrontiers in Immunology
dc.titleCytotoxic T Cell-Derived Granzyme B Is Increased in Severe Plasmodium Falciparum Malaria
dc.typeArticle
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