Sialic Acid, Metabolic and Anthropometric variables in type two diabetic patients.

Simple item page
dc.contributor.authorLarbi, Albert
dc.date.accessioned2017-01-18T10:52:46Z
dc.date.accessioned2023-04-19T12:24:25Z
dc.date.available2017-01-18T10:52:46Z
dc.date.available2023-04-19T12:24:25Z
dc.date.issuedNOVEMBER, 2016
dc.descriptionThesis submitted to the Department of Molecular Medicine, School of Medical Sciences College of Health in partial fulfilment of the requirements for the Award of Master of Philosophy in Chemical Pathology,en_US
dc.description.abstractType 2 diabetes mellitus is associated with higher cardiovascular risk partly related to an increase in inflammatory parameters. There is however a gap in the fight to early detection of microvascular complications in type 2 diabetes in Ghana. The objective of this study was to determine the relationship between sialic acid with metabolic variables in Ghanaian type 2 diabetes with and without microvascular complications. This case-control study comprising of 150 type 2 diabetic patients and 50 age-matched healthy individuals without diabetes were recruited. Fasting venous blood samples were collected and analyzed for total cholesterol, triglyceride, low-density lipoprotein, high-density lipoprotein, fasting glucose, glycated hemoglobin, sialic acid and C-reactive protein. Serum sialic acid levels were elevated in diabetic with retinopathy (230.68 ± 135.60mg/dl) followed by nephropathy (196.53 ± 61.19mg/dl) compared to diabetic patients with no complications (185.55 ± 75.69mg/dl) (p=0.065). Patients with type two diabetes had significantly higher C-reactive protein (p=0.026) and serum sialic acid (p<0.0001) compared to the non-diabetics. In the patients with diabetes, 14.7% were able to excellently control their blood glucose with 28.0% poorly controlling their glycaemia. Level of Serum sialic acid was higher in the patients with good control than those with poor control. However, C-reactive was higher in patients with poor control and lower in those with good control. The inflammatory markers showed no statistically significant difference on comparison. No statistically significant relationship (P>0.05) was established between the levels of serum sialic acid and blood glucose and glycated haemoglobin among patients with diabetes. C-reactive was inversely associated with blood glucose though not statistically significant, whereas it was directly associated with glycated. Serum sialic acid and C-reactive protein both showed inverse relationship with total cholesterol levels, triglycerides and low lipoprotein. However, a direct relationship between serum sialic acid and high density lipoprotein with no significance (r= 0.018, P=0.825) was observed. The main findings of this study is that raised serum sialic acid concentration is strongly related to the presence of microvascular complications in type two diabetes particularly retinopathy and nephropathy. Again this study indicated direct association of glycated with elevation of serum sialic acid and C-reactive protein. These may imply a significant relation between inflammation and glycemic control in people with established diabetes.en_US
dc.description.sponsorshipKNUSTen_US
dc.identifier.urihttps://ir.knust.edu.gh/handle/123456789/9938
dc.language.isoenen_US
dc.titleSialic Acid, Metabolic and Anthropometric variables in type two diabetic patients.en_US
dc.typeThesisen_US
Files
License bundle
Now showing 1 - 3 of 3
Thumbnail Image
Name:
license.txt
Size:
1.73 KB
Format:
Item-specific license agreed to upon submission
Description:
Download
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed to upon submission
Description:
Download
Thumbnail Image
Name:
SIALIC ACID1.pdf
Size:
1.68 MB
Format:
Adobe Portable Document Format
Description:
Full Theses
Download
Collections
College of Health Sciences