Genomic and epidemiological characteristics of SARS-CoV-2 in Africa

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dc.contributor.authorLamptey Jones
dc.contributor.authorOyelami Oluwapelumi Favour
dc.contributor.authorOwusu-Dabo Ellis
dc.contributor.authorNkrumah Bernard
dc.contributor.authorOwusu Michael....et a
dc.date.accessioned2023-12-11T10:19:12Z
dc.date.available2023-12-11T10:19:12Z
dc.date.issued2021
dc.descriptionThis article is published by Plos One and is also available at https://doi.org/10.1371/journal.pntd.0009335
dc.description.abstractince late 2019, the coronavirus disease 2019 (COVID-19) outbreak, caused by SARS CoV-2, has rapidly evolved to become a global pandemic. Each country was affected but with a varying number of infected cases and mortality rates. Africa was hit late by the pan demic but the number of cases rose sharply. In this study, we investigated 224 SARS-CoV 2 genome sequences from the Global Initiative on Sharing Avian Influenza Data (GISAID) in the early part of the outbreak, of which 69 were from Africa. We analyzed a total of 550 muta tions by comparing them with the reference SARS-CoV-2 sequence from Wuhan. We clas sified the mutations observed based on country and region, and afterwards analyzed common and unique mutations on the African continent as a whole. Correlation analyses showed that the duo variants ORF1ab/RdRp 4715L and S protein 614G variants, which are strongly linked to fatality rate, were not significantly and positively correlated with fatality rates (r = -0.03757, P = 0.5331 and r = -0.2876, P = 0.6389, respectively), although increased number of cases correlated with number of deaths (r = 0.997, P = 0.0002). Fur thermore, most cases in Africa were mainly imported from American and European coun tries, except one isolate with no mutation and was similar to the original isolate from Wuhan. Moreover, unique mutations specific to countries were identified in the early phase of the outbreak but these mutations were not regional-specific. There were common mutations in all isolates across the continent as well as similar isolate-specific mutations in different regions. Our findings suggest that mutation is rapid in SARS-CoV-2 in Africa and although
dc.description.sponsorshipKNUST
dc.identifier.citationLamptey J, Oyelami FO, Owusu M, Nkrumah B, Idowu PO, Adu-Gyamfi EA, et al. (2021) Genomic and epidemiological characteristics of SARS-CoV-2 in Africa. PLoS Negl Trop Dis 15(4): e0009335
dc.identifier.uri10.1371/ journal.pntd.0009335
dc.identifier.urihttps://ir.knust.edu.gh/handle/123456789/14735
dc.language.isoen
dc.publisherPLOS ONE
dc.titleGenomic and epidemiological characteristics of SARS-CoV-2 in Africa
dc.typeArticle
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