The phylogeography and incidence of multi-drug resistant typhoid fever in sub-Saharan Africa

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dc.contributor.authorPark Eun Se
dc.contributor.authorPham Thanh Duy
dc.contributor.authorOwusu-Dabo Ellis
dc.contributor.authorAseffa Abraham....et al
dc.date.accessioned2023-12-13T11:26:57Z
dc.date.available2023-12-13T11:26:57Z
dc.date.issued2018
dc.descriptionThis article is published by Springer Nature and is also available at https://doi.org/10.1038/s41467-018-07370-z
dc.description.abstractThere is paucity of data regarding the geographical distribution, incidence, and phylogenetics of multi-drug resistant (MDR) Salmonella Typhi in sub-Saharan Africa. Here we present a phylogenetic reconstruction of whole genome sequenced 249 contemporaneous S. Typhi isolated between 2008-2015 in 11 sub-Saharan African countries, in context of the 2,057 global S. Typhi genomic framework. Despite the broad genetic diversity, the majority of organisms (225/249; 90%) belong to only three genotypes, 4.3.1 (H58) (99/249; 40%), 3.1.1 (97/249; 39%), and 2.3.2 (29/249; 12%). Genotypes 4.3.1 and 3.1.1 are confined within East and West Africa, respectively. MDR phenotype is found in over 50% of organisms restricted within these dominant genotypes. High incidences of MDR S. Typhi are calculated in locations with a high burden of typhoid, specifically in children aged <15 years. Antimicrobial stewardship, MDR surveillance, and the introduction of typhoid conjugate vaccines will be critical for the control of MDR typhoid in Africa.
dc.description.sponsorshipKNUST
dc.identifier.citationPark, S.E., Pham, D.T., Boinett, C. et al. The phylogeography and incidence of multi-drug resistant typhoid fever in sub-Saharan Africa. Nat Commun 9, 5094 (2018). https://doi.org/10.1038/s41467-018-07370-z
dc.identifier.uri10.1038/s41467-018-07370-z
dc.identifier.urihttps://ir.knust.edu.gh/handle/123456789/14826
dc.language.isoen
dc.publisherSpringer Nature
dc.titleThe phylogeography and incidence of multi-drug resistant typhoid fever in sub-Saharan Africa
dc.typeArticle
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