Association of metabolic syndrome with the risk of developing liver disease in chronic hepatitis B patients

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dc.contributor.authorDongsogo, Julius
dc.contributor.authorChristopher, Larbie
dc.date.accessioned2020-09-28T13:22:42Z
dc.date.accessioned2023-04-19T02:14:54Z
dc.date.available2020-09-28T13:22:42Z
dc.date.available2023-04-19T02:14:54Z
dc.date.issued2019-02
dc.descriptionThis article is published in African Journal of Biochemistry Research and also available at DOI: 10.5897/AJBR2017.0956en_US
dc.description.abstractMetabolic syndrome is a constellation of abnormal glucose and lipid metabolic parameter that increases ones risk of developing cardiovascular diseases. Metabolic profiles have been linked to progression of varying stages of liver disease in chronic hepatitis B infection. The main objective of this prospective cross sectional study was to establish a link between metabolic syndrome indicators and markers of progression of liver disease in chronic hepatitis B infection. This could provide data leading to an alternative to managing the complications of chronic hepatitis B infection by possibly targeting metabolic precursors and their pathways which will be more targeting, sensitive and has minimal treatment complications than the conventional treatment regimes. In all, 200 chronic hepatitis B patients were sampled of which 100 met the United State National Cholesterol Education Program – Adult Treatment Panel III (US NCEP ATP III) 2005 criterion for metabolic syndrome. Anthropometric data and biochemistry analysis were performed. Obesity and dyslipidemia markers except HDL were higher in metabolic syndrome while haematological makers except WBC were lower in metabolic syndrome. Markers of liver carcinogenesis were generally higher in metabolic syndrome and strongly associated (p=0.01) with initial hepatocellular necrosis and cirrhosis stages of liver carcinogenesis than the intermediary fibrosis stages suggesting virologic mechanism may be responsible more for the fibrosis than metabolic factors. Metabolic syndrome was associated with the developing of various hepatitis B related liver complications. A long term study to elucidate viral genomic and dietary contributions to liver complications due to hepatitis B is necessary.en_US
dc.description.sponsorshipKNUSTen_US
dc.identifier.citationAfrican Journal of Biochemistry Research , Vol. 13(2), pp. 23-29,en_US
dc.identifier.uri10.5897/AJBR2017.0956
dc.identifier.urihttps://ir.knust.edu.gh/handle/123456789/13105
dc.language.isoenen_US
dc.publisherAfrican Journal of Biochemistry Researchen_US
dc.subjectMetabolic syndromeen_US
dc.subjectcardiovascular diseaseen_US
dc.subjectcarcinogenesisen_US
dc.subjectanthropometryen_US
dc.subjectchronic hepatitisen_US
dc.subjectdyslipidemiaen_US
dc.subjecthaematologicalen_US
dc.subjecthepatocellularen_US
dc.subjectfibrosis.en_US
dc.titleAssociation of metabolic syndrome with the risk of developing liver disease in chronic hepatitis B patientsen_US
dc.typeArticleen_US
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