Pathogens associated with hospitalization due to acute lower respiratory tract infections in children in rural Ghana: a case–control study

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dc.contributor.authorKrumkamp Ralf
dc.contributor.authorKohsar Matin
dc.contributor.authorOwusu-Dabo Ellis
dc.contributor.authorNolte Kolja...et al
dc.contributor.orcid0000-0003-4232-4292
dc.date.accessioned2023-12-13T15:26:24Z
dc.date.available2023-12-13T15:26:24Z
dc.date.issued2023
dc.descriptionThis article is published by Springer Nature and is also available at https://doi.org/10.1038/s41598-023-29410-5
dc.description.abstractRespiratory infections are one of the most common causes of death among children under the age of five years. Data on prevalence and relevance of specific organisms in African children are still lacking. This case–control-study investigated prevalence and relevance of specific organisms in Ghanaian children admitted to hospital with symptoms of lower respiratory tract infection (LRTI). Pharyngeal swabs were taken and tested by PCR for 19 respiratory isolates. Adjusted odds ratios (aORs) were calculated to estimate associations between isolates and admission with LRTI. Population attributable fractions (PAFs) were calculated to assess the proportion of LRTI cases due to a particular pathogen. The study included 327 cases and 562 controls. We found associations between detection and admission for LRTI for influenza (aOR 98.6; 95% confidence interval (CI) 20.0–1789.6), respiratory syncytial virus (aOR 40.2; 95% CI 7.2–758.6), H. influenzae (aOR 4.1; 95% CI 2.2–7.9) and S. pneumoniae (aOR 2.4; 95% CI 1.7–3.4). PAFs ≥ 10% were observed for S. pneumoniae (30%; 95% CI 26–42), H. influenzae (10%; 95% CI 2–19) and influenza (10%; 95% CI 2–18). This study highlights the need for heightened surveillance and development of effective vaccines for respiratory pathogens other than SARS-CoV-2 in the future.
dc.description.sponsorshipKNUST
dc.identifier.citationKrumkamp, R., Kohsar, M., Nolte, K. et al. Pathogens associated with hospitalization due to acute lower respiratory tract infections in children in rural Ghana: a case–control study. Sci Rep 13, 2443 (2023). https://doi.org/10.1038/s41598-023-29410-5
dc.identifier.uri10.1038/s41598-023-29410-5
dc.identifier.urihttps://ir.knust.edu.gh/handle/123456789/14834
dc.language.isoen
dc.publisherSpringer Nature
dc.titlePathogens associated with hospitalization due to acute lower respiratory tract infections in children in rural Ghana: a case–control study
dc.typeArticle
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