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|Title: ||Association between birth outcomes and aflatoxin B1 biomarker blood levels in pregnant women in Kumasi, Ghana|
|Authors: ||Williams, Jonathan H.|
Ellis, William Otoo
Person, Sharina D.
Ehiri, John E.
Jolly, Pauline E.
Shuaib, Faisal M. B.
|Issue Date: ||Feb-2010|
|Publisher: ||Tropical Medicine and International Health|
|Citation: ||Tropical Medicine and International Health doi:10.1111/j.1365-3156.2009.02435.x volume 15 no 2 pp 160–167 february 2010|
|Abstract: ||To investigate the association between birth outcomes and blood levels of aflatoxin B1
(AFB1)-lysine adduct in pregnant women in Kumasi, Ghana.
A cross-sectional study of 785 pregnant women attending antenatal clinic was conducted.
Aflatoxin B1 (AFB1)-lysine adduct levels were determined by high performance liquid chromatography
(HPLC) on blood taken after delivery. The birth outcomes considered were small for gestation age, low
birthweight, preterm delivery and stillbirth. Participants were divided into quartiles based on the distribution
of aflatoxin B1-lysine adducts in pg ⁄mg albumin (‘low’: £2.67, ‘moderate’: >2.67 to £4.97,
‘high’: >4.97 to £11.34, ‘very high’: >11.34). Statistical analysis involved models that included sociodemographic
variables and other potential confounders.
results The average AFB1-lysine adduct level in maternal serum was 10.9 ± 19.00 pg ⁄mg albumin
(range = 0.44–268.73 pg ⁄ mg). After adjusting for socio-demographic variables and potential confounding
factors, participants in the highest AFB1-lysine quartile with ‘very high’ AFB1-lysine level
(>11.34 pg ⁄ mg) were more likely to have low birthweight babies (OR, 2.09; 95% CI, 1.19–3.68), and
showed a trend of increasing risk for low birthweight (Ptrend = 0.007) compared to participants in the
This study adds to the growing body of evidence that aflatoxins may increase the risk of
adverse birth outcomes. The findings have implications for targeted nutritional education of pregnant
women in areas with high levels of aflatoxin contamination of foods|
|Description: ||This Article was published by Tropical Medicine and International Health doi:10.1111/j.1365-3156.2009.02435.x volume 15 no 2 pp 160–167 february 2010|
|Appears in Collections:||College of Science|
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