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|Title: ||Aflatoxin-Related Immune Dysfunction in Health and in Human Immunodeficiency Virus Disease|
|Authors: ||Williams, Jonathan H.|
Phillips, Timothy D.
Ellis, William Otoo
Jolly, Pauline E.
|Issue Date: ||2008|
|Publisher: ||Clinical and Developmental Immunology|
|Citation: ||Hindawi Publishing Corporation Clinical and Developmental Immunology Volume 2008, Article ID 790309, 12 pages doi:10.1155/2008/790309|
|Abstract: ||Both aflatoxin and the human immunodeficiency virus (HIV) cause immune suppression and millions of HIV-infected people
in developing countries are chronically exposed to aflatoxin in their diets. We investigated the possible interaction of aflatoxin
and HIV on immune suppression by comparing immune parameters in 116 HIV positive and 80 aged-matched HIV negative
Ghanaians with high (≥0.91 pmol/mg albumin) and low (<0.91 pmol/mg albumin) aflatoxin B1 albumin adduct (AF-ALB)
levels. AF-ALB levels and HIV viral load were measured in plasma and the percentages of leukocyte immunophenotypes and
cytokine expression were determined using flow cytometry. The cross-sectional comparisons found that (1) among both HIV
positive and negative participants, high AF-ALB was associated with lower perforin expression on CD8+ T-cells (P = .012);
(2) HIV positive participants with high AF-ALB had significantly lower percentages of CD4+ T regulatory cells (Tregs; P =
.009) and naive CD4+ T cells (P = .029) compared to HIV positive participants with low AF-ALB; and (3) HIV positive
participants with high AF-ALB had a significantly reduced percentage of B-cells (P = .03) compared to those with low AFALB.
High AF-ALB appeared to accentuate some HIV associated changes in T-cell phenotypes and in B-cells in HIV positive
|Description: ||This Article was published by Hindawi Publishing Corporation Clinical and Developmental Immunology Volume 2008, Article ID 790309, 12 pages doi:10.1155/2008/790309|
|Appears in Collections:||College of Science|
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