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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/7947

Title: Qualitative and quantitative evaluation of cryptolepis-based herbal formulations in Ghana
Authors: Mensah, Adelaide
Issue Date: 2-Nov-2015
Abstract: Cryptolepine is the first and main alkaloid isolated from the West African shrub Cryptolepis Sanguinolenta. Cryptolepine has been extensively studied and scientifically proven to exhibit antimuscarinic, antithrombotic, anti-inflammatory, anti-microbial, hypoglycaemic and antimalarial activities. It is also reported to be cytotoxic, being a DNA intercalator and a topoisomerase II inhibitor. In Ghana, Cryptolepis-based preparations which are mainly aqueous extracts of whole roots of Cryptolepis sanguinolenta are used as antimalarials. Currently, there are a number of branded Cryptolepis Sanguinolenta herbal formulations on the Ghanaian market. The proliferation of these brands calls for pharmacovigilance to ensure that spurious/falsely-labelled/falsified/counterfeit (SFFC) brands are identified to ensure the safety and quality of these formulations and hence improve malaria treatment outcomes.
Description: A Thesis submitted in partial fulfilment of the requirements for the award of Master of Philosophy Degree in Pharmaceutics, 2015
URI: http://hdl.handle.net/123456789/7947
Appears in Collections:College of Health Sciences

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