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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/7227

Title: Effects Of Combining Crude Ethanolic Extract Of Jatropha Curcus L. Leaf And Some Antibiotics Against Some Selected Microorganisms
Authors: Akanwariwiak, W. G
Addo-Fordjour, P
Musah, A A
Keywords: antimicrobial activity
crude ethanolic extract
Jatropha curcus leaf
diameter of inhibition zone
minimum inhibition concentration (MIC)
Issue Date: 2012
Publisher: Global Journal of Research on Medicinal Plants & Indigenous Medicine (GJRMI)
Citation: GJRMI, Volume 1, Issue 5, 2012
Abstract: Evidences are mounting concerning the resistance of microorganisms to antibiotics throughout the world. This development has awakened scientists to explore alternative approaches that target and block resistance. One way of accomplishing this has been the combination of plant extracts with antibiotics to increase their activity. The study was therefore, aimed at determining the effects of combining the leaf extract of Jatropha curcas L. with some antibiotics on certain selected microorganisms. The antimicrobial activity of the ethanolic extract of J. curcas leaf and its combination with selected antibiotics was assessed against certain microorganisms using the agar well diffusion method. The diameter of inhibition zone and minimum inhibitory concentration (MIC) were used as indicators of antimicrobial activity. The plant extract alone showed antimicrobial activity against all the test organisms, with diameter of inhibition zone ranging from 2–13.7 mm. The diameter of inhibition zone of the antibiotics alone ranged from 3.7–23 mm. The activity of the antibiotics varied upon combination with the plant extract, but the diameter of inhibition zone was between 6 and 25 mm. The antimicrobial activity of ciprofloxacin was increased significantly (MICs reduced significantly) when combined with the plant extract whereas that of tetracycline was reduced. In all, ciprofloxacin and ciprofloxacin-plant extract were the most effective treatments recording the lowest MICs. The most significant reduction of MICs was observed in the ciprofloxacin-plant extract combination.
Description: Article published in GJRMI, Volume 1, Issue 5, May 2012. Also available at www.gjrmi.com
URI: http://hdl.handle.net/123456789/7227
ISSN: 140–148
Appears in Collections:College of Science

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