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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/7116

Title: Antihyperglycaemic activity of ethanolic extract of the stem of adenia lobata engl (passifloraceae)
Authors: Sarkodie, J.A.
Fleischer, T.C.
Edoh, D.A.
Dickson, R.A.
Mensah, M.L.K.
Annan, K.
Woode, E.
Koffour, G.A.
Appiah, A.A.
Brew-Daniels, H.
Keywords: Adenia lobata
Antihyperglycaemic activity
Streptozotocin
Palmitic
Issue Date: 2013
Publisher: International Journal of Pharmaceutical Sciences and Research
Citation: IJPSR, 2013; Vol. 4(4): 1370-1377.
Abstract: Adenia lobata Engl (Passifloraceae) is a woody climber which grows in most African countries mainly the coastal belt. It is an important medicinal plant used to treat haemorrhoids, malaria, fever, diabetes and gonorrhea. In our attempt to find out the constituents of this medicinal plant, the dried stem powder of A. lobata was successively extracted by Soxhlet with petroleum ether and 70% ethanol to obtain the crude petroleum ether (PEAL: yield =1.1w/w %) and ethanol (EEAL: yield = 5.4 w/w %) extracts. The antihyperglycaemic activity of PEAL and EEAL were determined in streptozotocin-induced diabetic rats (70 mg/kg body weight). The ethanol extract was most active and was subjected to chromatographic separation to isolate its chemical constituents. The isolated compounds were identified using NMR spectroscopic namely 1H, 13C NMR, COSY, HSQC and HMBC Spectroscopy with reference to literature.
Description: Article published in International Journal of Pharmaceutical Sciences and Research(IJPSR) 2013; Vol. 4(4): 1370-1377. Also available online at www.ijpsr.com
URI: http://hdl.handle.net/123456789/7116
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