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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/7029

Title: A review of the anticancer potential of the antimalarial herbal cryptolepis sanguinolenta and its major alkaloid cryptolepine
Authors: Ansah, C.
Mensah, B.
Issue Date: Sep-2013
Publisher: Ghana Medical Journal
Citation: Ghana Medical Journal 2013 Volume 47, Number 3
Abstract: Cryptolepis sanguinolenta (Lindl.) Schltr (Periplocaceae), has a longstanding traditional use in the treatment of malaria in the West African region. Recent evidence suggests that the aqueous extract from the roots and the major alkaloid from the plant, cryptolepine, have prospects as cancer chemotherapeutic agents on account of their potent cytotoxicity to mammalian cells. Several mechanisms have been proposed to explain the cytotoxic activities of the agents. However, emerging evidence from their anti-inflammatory actions suggest that the mechanism of the cytotoxicity may be closely related to its antiinflammatory activity. This review looks at the mechanisms of cryptolepis-induced cytotoxicity, its link with inflammation and its potential as anticancer agent. The elucidation of these interwoven mechanisms may be useful in the development of cryptolepine or other analogues as new anticancer agents.
Description: Ghana Medical Journal,September 2013 Volume 47, Number 3
URI: http://hdl.handle.net/123456789/7029
Appears in Collections:College of Health Sciences

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