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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/6743

Title: Hepatitis E virus infections in HIV-infected patients in Ghana and Cameroon
Authors: Feldt, T
Sarfo, FS
Zoufaly, A
Phillips, RO
Burchard, G
van Lunzen, J
Jochum, J
Chadwick, D
Awasom, C
Claussen, L
Drosten, C
Drexler, JF
Eis-Hübinger, AM
Keywords: ALT
ART
AST
Africa south of the Sahara
Chronic hepatitis
HBV
HBsAg
HCV
HEV
HIV
IQR
IgG
RT-PCR
SD
Seroprevalence
alanine aminotransferase
antiretroviral
therapy
aspartate aminotransferase
hepatitis B virus
hepatitis B virus surface antigen
hepatitis C virus
hepatitis E virus
human immunodeficiency virus
immunoglobulin G
immunoglobulin C virus
interquartile range
reverse transcription polymerase chain reaction
standard deviation
Issue Date: Sep-2013
Publisher: J Clin Virol
Citation: J Clin Virol. 2013 Sep;58(1):18-23
Abstract: Chronic hepatitis E virus (HEV) infections have recently been described in HIV-infected patients. Only few data are available for sub-Saharan Africa, where HIV and HEV are highly co-endemic, and where liver pathology is common in HIV-infected individuals. OBJECTIVES: To assess the prevalence of HEV viremia, anti-HEV antibodies, and serum aminotransferase levels in HIV patients in Ghana and Cameroon. STUDY DESIGN: We retrospectively surveyed a cross-section of patients who were enrolled in cohort studies in Ghana (West Africa), and Cameroon (Central Africa). Plasma samples from 1029 HIV patients from Ghana and 515 patients from Cameroon including 214 children were analyzed for HEV-RNA by two reverse transcription PCR methods. In a subset of 791 patients, anti-HEV IgG and IgM antibodies were analyzed. RESULTS: No HEV-RNA was detected in any of the plasma samples of 1544 patients. HEV seroprevalence was high in adult HIV patients from Ghana (45.3%, n=402) and Cameroon (14.2%, n=289), but low in pediatric HIV patients from Cameroon (2.0%, n=100). Elevations of alanine aminotransferase and aspartate aminotransferase levels were common in adult patients from Ghana (20.8% and 25.4%) and Cameroon (38.9% and 69.8%). The prevalence of hepatitis B virus surface antigen was 11.8% and of hepatitis C virus antibodies 2.5% in our adult Cameroonian study population.
Description: Article published in J Clin Virol. 2013 Sep;58(1):18-23. Also available at doi: 10.1016/j.jcv.2013.05.004
URI: http://hdl.handle.net/123456789/6743
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