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|Title: ||Biochemical and Haematological Profile of Diabetic Nephropathy|
|Authors: ||Asamoah-Boadi, Helen|
End Stage Renal Disease
|Issue Date: ||18-Jul-2012|
|Abstract: ||Background: Diabetic nephropathy, a microvascular complication of diabetes mellitus is now
considered to be the leading known cause of end-stage renal disease (ESRD) in most countries.
The objective of this study is to establish the haematological and biochemical profile of patients
with diabetic nephropathy, so as to gain as much knowledge as possible about the disease, to
help prevent the complication where possible and improve the quality of life of those affected.
Method: A total of 101 type 2 diabetics with microalbuminuria (63) and overt nephropathy (38)
were recruited for the study. 52 diabetics without nephropathy were recruited as controls.
Structured questionnaires were administered to them and their venous blood samples taken for
biochemical and haematological assays.
Results: The mean age of the study group was 57.5 (± 9.6) years. Duration of disease and
systolic blood pressure were significantly higher in the patient group (p<0.05).
Total WBC and neutrophil count were also significantly higher in the patient group as compared
Fasting blood sugar, serum albumin, globulin, total cholesterol and LDL cholesterol were found
to be significantly higher in the patient group (p<0.05). Serum urea, creatinine, sodium, chloride
and total iron were also significantly higher in the group. eGFR and serum vitamin B12 were
found to be significantly lower in the patient group.
Conclusion: Diabetics who develop microalbuminuria and nephropathy have several
haematological and biochemical abnormalities, and these should be assessed and analysed
periodically to help effectively manage their conditions.|
|Description: ||A Thesis Submitted to the Department of Molecular Medicine,School of Medical Sciences, Kwame Nkrumah University of Science and Technology,
in fulfillment of the requirements for the Degree of Master of Philosophy in Chemical Pathology, July-2012|
|Appears in Collections:||College of Health Sciences|
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