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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/5234

Title: Friedelin: A Bacterial Resistance Modulator from Paullinia Pinnata L.
Authors: Annan, K.
Adu, F.
Gbedema, S.Y.
Keywords: Paullinia pinnata
resistance modulators
Staphyloccocus aureus
Issue Date: Apr-2009
Publisher: Journal of Science and Technology
Citation: Journal of Science and Technology, Vol. 29 No. 1, 2009 pp 152-159
Abstract: As part of the project to identify plant natural products which modulate bacterial multidrug resistance (MDR), bioassay-guided isolation of the methanol extract of Paullinia pinnata L. roots yielded four known compounds namely friedelin, β-sitosterol, β-sitosterol acetate and β-sitosterol D- glucoside. The structures were established by spectroscopic methods and comparison with published data. These compounds were tested for in vitro antibacterial and resistance modifying activities against strains of Staphylococcus aureus; SAI199B, RN4220 and XU212 possessing the Tet(K), Mu (A), and Nor(A) multidrug resistance efflux mechanisms respectively. At lOµg/ml, none of the cm pounds displayed any antibacterial action but in combination with tetracycline, erythromycin suit norfloxacin, friedelin displayed a 2-fold, 4-fold and 16-fold potentiation of activities of these antibioics against XU212, SA1199B and RN4220 possessing the Tet(K) [tetracycline resistant/), Nor(A) (norfloxacin resistant)/ and Msr(A) (macrolide resistant) transporters respectively.
Description: Article published in the Journal of Science and Technology, Vol. 29 No. 1, 2009 pp 160-168
URI: http://hdl.handle.net/123456789/5234
Appears in Collections:Journal of Science and Technology 2000-

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