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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/5189

Title: Toxicity Studies on Alchornea Cordifolia Leaf extract in Mice
Authors: Ansah, C.
Oppong, E.
Woode, E.
Duwiejua, M.
Keywords: Alchornea toxicity
mice
blood cells
blood chemistry
Issue Date: Apr-2009
Publisher: Journal of Science and Technology
Citation: Journal of Science and Technology, Vol. 29 No. 1, 2009 pp 8-16
Abstract: Alchornea cordifolia (Schum. and Thonn.) Miill. Arg (Euphorbiaceae), a widely used traditional medicinal agent was assessed for possible toxicity in mice. We investigated the effect of the ethanolic extract of Alchornea on blood cells and chemistry, histology, and relative weight of selected organs in mice. Administration of Alchornea cordifolia (250-2000 mg/kg, p.o daily) for two weeks did not affect significantly the relative organ weights, blood cells or renal function. Histology of liver and kidney at dose levels up to 1000 mg/kg was normal and similar to vehicle-treated controls. However, liver sections of mice treated with 2000 mg/kg Alchornea extract showed perivascular aggregates of lymphocytes, eosinophilia and pyknosis, evidence of hepatic damage. These results suggest that Alchornea cordifolia is relatively non-toxic but has the propensity to induce hepatic injury at high doses.
Description: Article published in the Journal of Science and Technology, Vol. 29 No. 1, 2009 pp 8-16
URI: http://hdl.handle.net/123456789/5189
Appears in Collections:Journal of Science and Technology 2000-

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