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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/5148

Title: In Vitro Evaluation of Effects of Two Ghanaian Plants Relevant to Wound Healing
Authors: Mensah, Abraham Y.
Houghton, Peter J.
Dickson, Rita A.
Fleischer, Theophilus C.
Heinrich, M.
Bremner, P.
Keywords: Commelina diffuse
Spathodea campanulata
Ringworm fungi
Wound healing
Lipid peroxidarion
Issue Date: 14-Aug-2006
Publisher: Phytotherapy Research
Citation: Phytotherapy Research, 20, 941-944 (2006)
Abstract: Commelina diffusa and Spathodea campanu/ata are used as wound-healing agents in Ashanti traditional medicine in Ghana. The methanol extracts of Commelina diffusa herb and Spathodea campanulata bark showed some level of antimicrobial activity with C. diffusa exhibiting selective antifungal activity against Trichophyton species. The extracts reduced the peroxidation of bovine brain extract with an IC50 value of 1.39 ug/mL and 0.24 ug/mL, respectively. In addition the extracts also exhibited significant antioxidant activity by protecting MRC-5 cells from hydrogen peroxide induced oxidant injury at concentrations between 1 ug/mL and 10 ug/mL. The extracts showed no inhibition of NF-Idl at 100 ug/mL. The antioxidant activities and antimicrobial activities suggest that the use of the plants in wound healing may be based 011 antioxidant and antiseptic effects of its constituents.
Description: This article was published by Phytotherapy Research, 20, 941-944 (2006)
URI: http://hdl.handle.net/123456789/5148
Appears in Collections:College of Health Sciences

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