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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/5140

Title: Antimicrobial, Resistance-Modifying Effects, Antioxidant and Free Radical Scavenging Activities of Mezoneuron benthamianum Baill., Securinega virosa Roxb. &Wlld. and Microglossa pyrifolia Lam.
Authors: Dickson, R. A.
Houghton, P. J.
Hylands, P. J.
Gibbons, S.
Issue Date: 16-Sep-2006
Publisher: Phytotherapy Research
Citation: Phytotherapy Research, Vol. 10, Pgs. 41--45 (2006)
Abstract: Mczoncuron benthamianum, Securinega virosa and Microglossa pyrifolia are used in folk medicine in Ghana for the treatment of dermal infections and wounds. Petroleum spirit, chloroform and ethanol extracts of the plants were tested for antimicrobial activity.against a battery of organisms using the agar wen diffusion technique und a serial dilution micro assay. The resistance modifying activities of these extracts on standard antibiotics against Staphylococcus aureus possessing efflux mechanisms of resistance have also been assessed. A 4-fold potentiation of the activity of norfloxacin was observed for ethanol and chloroform extracts of M. bentluunlanum nud S. virosa, respectively, whilst the petroleum spirit extract resulted in a 2-fold potentiation with mlnimum inhibitory concentration (MIC) values in the range 8-16ug/mL. Ethanol extracts of all three species, the petrulcuu; sl,irit extract of M. benthamianum and the chloroform extracts of M. benthamianum and S. vlrosa, showed Interesting antimicrobial activities. Antioxidant and free radical scavenging activities using DPPH spectrophotometric and TBA lipid peroxidation assays were also conducted. Of the five extracts that showed antioxidant activities, the petroleum spirit and chloroform extracts of M. benthamianum rated most highly by displaying strong free radical scavenging activity with IC5o values of 15.33 and 19.72 ug/mL, respectively, Lipid peroxldutlon inhibition provided by the same two extracts also produced the lowest IC5o values for all the values tested, of 23.15 and 30.36 ug/mL. These findings therefore give some support to the ethnopharmacological use or the plants in the treatment of various skin diseases and wounds, as well as demonstrating the potential of some of the plants as sources of compounds possessing the ability to modulate bacterial multidrug resistance.
Description: This article was published by Phytotherapy Research, Vol. 10, Pgs. 41--45 (2006)
URI: http://hdl.handle.net/123456789/5140
Appears in Collections:College of Health Sciences

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