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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/5095

Title: Comparative Performance of Neem (Azadiracta Indica) Seed Extract and Mebendazole (Vermox) against Naturally Occuring Helminths in Rats (Rattus Nor Vegicus)
Authors: Lawson, B. W.
Tuani, G K
Dompreh, A.
Keywords: Toxicological
anti-helminthic,
efficacy
Azadirachta indica
Issue Date: 2003
Publisher: Journal of Science and Technology
Citation: Journal of Science and Technology Vol. 23 No. 2 pp 1-10
Abstract: The anti-helminthic efficacy of the neem (Azadiracta indica ) seed extracts in alcohol was evaluated in comparison with Mebendazole (Vermox) a broadspectrum, standard anti-helminthic drug. Thirty-two albino rats (Rattus norvegicus) naturally infected with the helminth species, Hymenolepis diminuta, Enterobius vermicularis and hookworm were treated with the alcoholic extract of the neem seed and Mebendazole in separate groups, with appropriate controls, over a three-week period. Faecal samples from the rats were collected periodically, and examined for helminth eggs. The results showed that concentrations of the neem seed extract ranging from 20% to 60% administered 2.0 ml orally per rat in a single dose were effective against the worms by the third week whereas Mebendazole administered at 70mg per/kg body weight of the rats for three consecutive days was effective against all three nematodes by the second week following administration . Rats treated with the 60% alcoholic extract of neem seed showed a reduction in weight compared with the Mebendazole treated rats, and also recorded a mortality. Further studies on the extract are recommended to ascertain its possible toxicological effects and potency as an anti-helminthic.
Description: Article published in the Journal of Science and Technology,Vol. 23, No. 2 pp 1-10
URI: http://hdl.handle.net/123456789/5095
ISSN: 08550395
Appears in Collections:Journal of Science and Technology 2000-

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