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http://hdl.handle.net/123456789/5081
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Title: | RP-LC Determination of Ascorbic Acid, Paracetamol and Caffeine in Multicomponent Anti-Cold Preparation |
Authors: | Okine, N.N.A. Asiedu, K.S. Acheampong, J. |
Keywords: | Ascorbic acid Paracetamol caffeine benzoic acid RP-LC |
Issue Date: | 2003 |
Publisher: | KNUST |
Citation: | Journal of Science and Technology, Vol. 23 No.1, pp 54-61 |
Abstract: | An RP-LC method for the simultaneous determination of ascorbic acid, paracetamol and caffeine in a tablet matrix is described. The mobile phase was a mixture of methanol-NaH2PO4 (17:83 pH 4.25 ±0.05) and stationary phase Aquapore RP-300. Total chromatographic time was approximately 8 minutes and the method found to be cost effective. The method was used to analyze some brands of multi-component anti cold preparations on the local market. Results were validated using the standard UV spectrophotometric methods for the assay of the individual components of these drugs. |
Description: | Article published in the Journal of Science and Technology, Vol. 23 No.1, pp 54-61 |
URI: | http://hdl.handle.net/123456789/5081 |
ISSN: | 08550395 |
Appears in Collections: | Journal of Science and Technology 2000-
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