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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/4034

Title: Formulation and evaluation of capsules from Asena and Enterica preparations supplied by Centre for Scientific Research into Plant Medicine (CSRPM), Mampong, Ghana
Authors: Kumadoh, Doris
Issue Date: 19-Jun-2011
Abstract: The project sought to transform two decoctions (Asena and Enterica) produced by the Centre for Scientific Research into Plant Medicine for the treatment of arthritis and typhoid fever respectively into capsules. The amount of extract per dose (30ml) of Asena was 400mg. The amount of extract per dose (30ml) of Enterica was 190mg. Adsorbents were used to adsorb water to enhance processing of extracts due to their inability to dry completely in large doses. Five adsorbents (maize starch, light magnesium carbonate, bentonite, kaolin, microcrystalline cellulose) were initially investigated to ascertain their ease of processing into granules with thin viscous extracts of decoctions obtained by drying in the Oven at 60OC. For Asena the amount of adsorbent per dose used for initial investigation was 200mg. This amount was ascertained by determining the amount of extract of Asena that was able to fill a 500mg capsule shell. With Enterica, the amount of adsorbent per dose used for the same purpose was 110mg. This was ascertained by determining the amount of Enterica extract that was able to fill a 250mg capsule shell. The release of the extract in the formulated granules was also determined at 45minutes. For Asena light Magnesium carbonate, maize starch and bentonite were used at five different weights of 40mg, 80mg, 160mg, 180mg and 200mg per dose of Asena decoction for further investigation. The adsorbent was used to form a paste with thin viscous extracts of the decoction obtained by drying of decoction in the oven at 60OC.The paste was then allowed to dry to a constant weight. The ease of processing of adsorbent extract mix formed after drying into granules was recorded. The percentage loss in weight of granules was determined. The flow properties of the formulated granules were also determined using the fixed height cone, Carr’s index and Hausner ratio methods.
Description: A Thesis submitted to the Department of Pharmaceutics, Kwame Nkrumah University of Science and Technology, in partial fulfillment of the requirements for the degree of Master of Philosophy in Pharmaceutics, 2011
URI: http://hdl.handle.net/123456789/4034
Appears in Collections:College of Health Sciences

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