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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/15685

Title: The Lambare´ne´ Organ Dysfunction Score (LODS) Is a Simple Clinical Predictor of Fatal Malaria in African Children
Authors: Agbenyega, Edward Tsiri
Schmutzhard, Erich
Kremsner, Peter Gottfried
Helbok, Raimund
Kendjo, Eric
Issifou, Saadou
Lackner, Peter
Newton, Charles R.
Kombila, Maryvonne
Bojang, Kalifa
Dietz, Klaus
Issue Date: 25-May-2009
Publisher: Infectious Diseases Society of America
Citation: Infectious Diseases Society of America, 2009
Abstract: Background. Plasmodium falciparum malaria accounts for 11 million deaths annually, mostly among young children in sub-Saharan Africa. Identifying those individuals who are likely to die is crucial. Several factors have been independently associated with death. Because malaria is a systemic disease, a quantitative score combining such risk factors may be superior. Methods. We used both forward and backward stepwise logistic regression to select the best predictors of death, as evaluated for 23,890 African children with severe P. falciparum malaria. The study was conducted from December 2000 through May 2005 in 6 hospital-based research units (in Banjul in the Gambia, Blantyre in Malawi, Kilifi in Kenya, Kumasi in Ghana, and Lambare´ne´ and Libreville in Gabon) in a network established to study severe malaria in African children (ie, the SMAC Network). Results. The Lambare´ne´ Organ Dysfunction Score (LODS) combines 3 variables: coma, prostration, and deep breathing. A LODS 10 (odd ratio, 9.6; 95% confidence interval, 8.0–11.4) has 85% sensitivity to predict death, and a LODS !3 is highly (98%) specific for survival. Conclusions. The LODS is a simple clinical predictor of fatal malaria in African children. This score provides accurate and rapid identification of children needing either referral or increased attention.
Description: This article is published at Infectious Diseases Society of America
URI: http://hdl.handle.net/123456789/15685
Appears in Collections:College of Health Sciences

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