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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/14495

Title: Hypermetabolic response of burn patients at Komfo Anokye Teaching Hospital (KATH)
Authors: Opoku, Kwame
Yeboah, Francis. A.
Keywords: Hypermetabolic
Burn Patients
Komfo Anokye Teaching Hospital (KATH
Issue Date: 23-Jul-2021
Abstract: Burns are one of the most common causes of trauma reported to clinics and emergency centers throughout the world causing mortality and damaging morbidity. Severe burn injuries are the main reason of prolonged hospital stay, deformity, disability, and demise particularly in Africa. One major complication associated with severe burns is the development of hypermetabolism in patients which may be sustained for long periods. Serial assessments of the biochemical metabolic parameters surely play a vital role for the metabolic management of burn patients hence this study is to assess hypermetabolic responses associated with burn injuries. The study was a hospital-based case control study conducted from April 2017 to February 2018 at the Department of Surgery (Burns Unit), Komfo Anokye Teaching Hospital (KATH). Thirty-three (33) subjects with no known chronic clinical conditions were recruited as controls whereas sixty-seven (67) burn patients on admission at Burns Intensive Care Unit (BICU) and Old Burns Ward D2C at KATH were also enrolled as cases. Parameters of interest in this study were total protein, albumin, sodium (Na+), potassium (K+), urea, glucose, Full blood count (FBC) and calculated osmolality (2Na+ + Urea + Glucose). With the full blood count measurement, levels of hemoglobin (HB), red blood cell count (RBC), white blood cell count (WBC), and hematocrit (HCT) level were taken into consideration. Serum electrolytes assay, total protein, albumin and urea were also carried out. A level of p<0.05 was considered as statistically significant for all analysis.The prevalence of burns among children (≤17 years) was observed among ages between 0-4 years. Hemoglobin, red blood cell and hematocrit levels was reduced significantly in the burn cases compared to the controls with a p-value of <0.001, 0.25 and <0.001 respectively which contributed to anemia in the burn patients with >10% total body surface area (TBSA). White blood cell (WBC) count of controls (7.0±3.0) to burn cases (13.5±6.2) was observed to be statistically significant with p-value ≤0. 0001.Serum sodium, serum potassium, serum urea and calculated osmolality, in the burn cases as compared to control subjects were observed to be statistically significant having p-values of 0.003, <0.001, <0.001 and 0.002 respectively. The association between hypermetabolic response and severe burns (≥40% TBSA) showed a statistical significant difference (p=0.008 and 0.010) in total protein and albumin suggesting that severe burns are associated with loss of total protein and albumin. On the other hand, the most occurring anatomical sites in burn injury was observed to affect the upper limbs of the body
Description: A thesis submitted to the Department of Molecular Medicine in partial fulfillment of the requirements for the Degree of Master of Philosophy (Chemical Pathology) in the Department of Molecular Medicine, School of Medical Sciences College of Health
URI: http://hdl.handle.net/123456789/14495
Appears in Collections:College of Health Sciences

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