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Title: | Dipstick urinalysis findings in children with Plasmodium falciparum in the South Tongu District: A case-control study |
Authors: | Ephraim, Richard K. D. Tashie, Worlanyo Agbodzakey, Hope Sakyi, Samuel Asamoah Essien-Baidoo, Samuel Adoba, Prince Adu, Patrick Ampong, Joyce |
Keywords: | Children Dipstick Malaria Plasmodium falciparum Urinalysis |
Issue Date: | 2015 |
Publisher: | Nigerian Medical Journal |
Citation: | Ephraim RK, Tashie W, Agbodzakey H, Sakyi SA, Essien-Baidoo S, Adoba P, et al. Dipstick urinalysis fi ndings in children with Plasmodium falciparum in the South Tongu District: A case-control study. Niger Med J 2015;56:292-6. |
Abstract: | some of the poorest countries in tropical and sub-tropical regions across the globe. We
determined urinary abnormalities and its relationship with parasite density in children ≤12 years
with Plasmodium falciparum infection. Materials and Methods: From December 2013 to
March 2014, we randomly recruited 116 participants comprising 58 malaria patients (cases)
and 58 healthy controls from the Comboni Mission and the Sogakope District Hospitals both
in the South Tongu district. Blood was collected for the estimation of hemoglobin and total
white blood cells; thick and thin blood films were used for the determination of malaria parasite
density. Urine was collected for the measurement of the various biochemical components using
the automated urine analyzer. A pretested questionnaire was used to obtain demographic
and clinical data. Results: Urine protein (P < 0.001), blood (P < 0.001), bilirubin (P < 0.001),
urobilinogen (P < 0.001), and ketones (P = 0.001) were significantly higher in individuals with
P. falciparum infection than in healthy controls. Proteinuria (P = 0.247; r = 0.155), hematuria
(P = 0.142; r = 0.195), bilirubinuria (P = 0.001; r = 0.438), urobilinogenuria (P = 0.876; r = 0.021),
and ketonuria (P = 0.136; r = 0.198) were positively correlated with malaria parasite density;
however, only bilirubinuria was significantly higher at higher parasitemia. Conclusion:
Malaria has a significant effect on the chemical composition of urine with bilirubin positively
correlated with parasite density. Dipstick urinalysis can be used together with light microscopy
in resource-limited malaria-endemic areas to accurately diagnose falciparum malaria infection. |
Description: | An article published by Ephraim RK, Tashie W, Agbodzakey H,
Sakyi SA, Essien-Baidoo S, Adoba P, et al. Dipstick urinalysis
fi ndings in children with Plasmodium falciparum in the South Tongu
District: A case-control study. Niger Med J 2015;56:292-6. |
URI: | http://hdl.handle.net/123456789/13637 |
Appears in Collections: | College of Health Sciences
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