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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/13637

Title: Dipstick urinalysis findings in children with Plasmodium falciparum in the South Tongu District: A case-control study
Authors: Ephraim, Richard K. D.
Tashie, Worlanyo
Agbodzakey, Hope
Sakyi, Samuel Asamoah
Essien-Baidoo, Samuel
Adoba, Prince
Adu, Patrick
Ampong, Joyce
Keywords: Children
Dipstick
Malaria
Plasmodium falciparum
Urinalysis
Issue Date: 2015
Publisher: Nigerian Medical Journal
Citation: Ephraim RK, Tashie W, Agbodzakey H, Sakyi SA, Essien-Baidoo S, Adoba P, et al. Dipstick urinalysis fi ndings in children with Plasmodium falciparum in the South Tongu District: A case-control study. Niger Med J 2015;56:292-6.
Abstract: some of the poorest countries in tropical and sub-tropical regions across the globe. We determined urinary abnormalities and its relationship with parasite density in children ≤12 years with Plasmodium falciparum infection. Materials and Methods: From December 2013 to March 2014, we randomly recruited 116 participants comprising 58 malaria patients (cases) and 58 healthy controls from the Comboni Mission and the Sogakope District Hospitals both in the South Tongu district. Blood was collected for the estimation of hemoglobin and total white blood cells; thick and thin blood films were used for the determination of malaria parasite density. Urine was collected for the measurement of the various biochemical components using the automated urine analyzer. A pretested questionnaire was used to obtain demographic and clinical data. Results: Urine protein (P < 0.001), blood (P < 0.001), bilirubin (P < 0.001), urobilinogen (P < 0.001), and ketones (P = 0.001) were significantly higher in individuals with P. falciparum infection than in healthy controls. Proteinuria (P = 0.247; r = 0.155), hematuria (P = 0.142; r = 0.195), bilirubinuria (P = 0.001; r = 0.438), urobilinogenuria (P = 0.876; r = 0.021), and ketonuria (P = 0.136; r = 0.198) were positively correlated with malaria parasite density; however, only bilirubinuria was significantly higher at higher parasitemia. Conclusion: Malaria has a significant effect on the chemical composition of urine with bilirubin positively correlated with parasite density. Dipstick urinalysis can be used together with light microscopy in resource-limited malaria-endemic areas to accurately diagnose falciparum malaria infection.
Description: An article published by Ephraim RK, Tashie W, Agbodzakey H, Sakyi SA, Essien-Baidoo S, Adoba P, et al. Dipstick urinalysis fi ndings in children with Plasmodium falciparum in the South Tongu District: A case-control study. Niger Med J 2015;56:292-6.
URI: http://hdl.handle.net/123456789/13637
Appears in Collections:College of Health Sciences

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