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|Title: ||CKD-EPI is a Better Tool for Detecting Renal Dysfunction in Hypertensive Pregnancy: A Case-Control Study in Ghana|
|Authors: ||Fondjo, Linda Ahenkorah|
Sakyi, Samuel Asamoah
Ephraim, Richard K.D
|Issue Date: ||2018|
|Publisher: ||Journal of Vascular Medicine & Surgery|
|Citation: ||Journal of Vascular Medicine & Surgery; 2018, 6:2 DOI: 10.4172/2329-6925.1000361|
|Abstract: ||sessed the use of CKD-EPI and 4v-MDRD for early diagnosis of renal impairment in pregnant women with
Methods: This case-control study was conducted at Suntreso Government Hospital Kumasi, Ghana. In all, 220
pregnant women were recruited, 84 had Gestational Hypertension, 36 had Preeclampsia, with 100 normotensive
pregnant women as controls. Structured Questionnaires were used to obtain socio-demographic and clinical
information. 4 mL of venous blood was collected for estimation of electrolytes, urea, creatinine and uric acid; urine
was collected for estimation of protein using dipstick. The Chronic Kidney Disease Epidemiology Collaboration
(CKD-EPI) and Modification of Diet in Renal Disease (MDRD-4) equations were used to assess and classify renal
Results: Prevalence of renal impairment using CKD-EPI and MDRD-4 was 4.1% and 0.5% respectively. CKDEPI
identified 22.2% of women with preeclampsia as having renal impairment whereas MDRD-4 identified 2.8%.
Using CKD-EPI and MDRD-4, eGFR was significantly higher in the controls compared to the cases, (p<0.001).
Sodium, chloride, urea, creatinine, uric acid was significantly increased in the hypertensive women.
Conclusion: Renal impairment is common in hypertensive pregnant women. CKD-EPI is better equation in early
detection of renal impairment in pregnant women and should be adopted as the tool for assessing renal dysfunction
during routine antenatal examinations to prevent end-stage renal diseases.|
|Description: ||An article published in Journal of Vascular Medicine & Surgery; 2018, 6:2; DOI: 10.4172/2329-6925.1000361|
|Appears in Collections:||College of Health Sciences|
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