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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/13589

Title: Evaluating the Contribution of Nocardia spp.andMycobacterium tuberculosis to Pulmonary Infections among HIV and Non-HIV Patients at the Komfo Anokye Teaching Hospital, Ghana
Authors: Sakyi, Samuel Asamoah
Danquah, Kwabena Owusu
Ephraim, Richard Dadzie
Enimil, Anthony
Frimpong, Venus
Fondjo, Linda Ahenkorah
Darkoh, Esther Love
Issue Date: 2018
Publisher: Canadian Journal of Infectious Diseases and Medical Microbiology
Citation: Canadian Journal of Infectious Diseases and Medical Microbiology, Volume 2018, Article ID 2910198, 7 pages, https://doi.org/10.1155/2018/2910198
Abstract: Tuberculosis (TB) is a major cause of human mortality particularly in association with the human immunodeficiency virus (HIV). Nocardia spp. has emerged as an opportunistic infection especially in HIV patients. 'e high prevalence of TB and HIV coupled with the lack of a definitive laboratory diagnosis for Nocardia spp. could lead to misdiagnosed pulmonary TB. 'is study determined the prevalence of pulmonary infections due to Nocardia spp. and Mycobacterium tuberculosis in sputum of HIV and non-HIV patients with suspected pulmonary tuberculosis at KATH. A total of sixty sputum samples were obtained from HIV and non-HIV patients with suspected pulmonary tuberculosis. Samples were examined by fluorescence based Ziehl–Neelsen staining, culture, and PCR methods. 'e prevalence of Nocardia spp. and Mycobacterium tuberculosis was 18.3% and 20%, respectively, with the latter having the highest rate among patients aged 21–40 years (P � 0.075). 'e prevalence of Nocardia spp. among HIV patients was 90.9% whilst 16.7% of the patients had HIV/Nocardia spp. coinfection. Detection of Mycobacterium tuberculosis by fluorescence-based Ziehl–Neelsen staining, culture, and PCR yielded 9 (15%), 11 (18.3%), and 12 (20%), respectively. 'ere is a high prevalence of nocardiosis especially in HIV patients. PCR is a better diagnostic method that detects both Nocardia spp. and Mycobacterium tuberculosis and should be incorporated into routine diagnosis for pulmonary infections.
Description: An article published in Canadian Journal of Infectious Diseases and Medical Microbiology, Volume 2018, Article ID 2910198, 7 pages, https://doi.org/10.1155/2018/2910198
URI: http://hdl.handle.net/123456789/13589
Appears in Collections:College of Health Sciences

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