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Title: | Organ damage in sickle cell disease study (ORDISS): protocol for a longitudinal cohort study based in Ghana |
Authors: | Anie, Kofi A Paintsil, Vivian Owusu-Dabo, Ellis Ansong, Daniel Osei-Akoto, Alex ..et.. al |
Issue Date: | 2017 |
Publisher: | BMJ Open |
Abstract: | Introduction Sickle cell disease is highly prevalent
in Africa with a significant public health burden.
Nonetheless, morbidity and mortality in sickle cell disease
that result from the progression of organ damage is
not well understood. The Organ Damage in Sickle Cell
Disease Study (ORDISS) is designed as a longitudinal
cohort study to provide critical insight into cellular and
molecular pathogenesis of chronic organ damage for the
development of future innovative treatment.
Methods and analysis ORDISS aims to recruit children
aged 0–15 years who attend the Kumasi Centre for Sickle
Cell Disease based at the Komfo Anokye Teaching Hospital
in Kumasi, Ghana. Consent is obtained to collect blood
and urine samples from the children during specified
clinic visits and hospitalisations for acute events, to
identify candidate and genetic markers of specific
organ dysfunction and end-organ damage, over a 3 year
period. In addition, data concerning clinical history
and complications associated with sickle cell disease
are collected. Samples are stored in biorepositories
and analysed at the Kumasi Centre for Collaborative
Research in Tropical Medicine, Ghana and the Centre for
Translational and International Haematology, University of
Pittsburgh, USA. Appropriate statistical analyses will be
performed on the data acquired.
Ethics and dissemination Research ethics approval was
obtained at all participating sites. Results of the study will
be submitted for publication in peer-reviewed journals, and
the key findings presented at national and international
conferences. |
Description: | This article is published in BMJ Open and is also available at doi:10.1136/bmjopen-2017-016727 |
URI: | 10.1136/bmjopen-2017-016727 http://hdl.handle.net/123456789/13451 |
Appears in Collections: | College of Agric and Natural Resources
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