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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/13451

Title: Organ damage in sickle cell disease study (ORDISS): protocol for a longitudinal cohort study based in Ghana
Authors: Anie, Kofi A
Paintsil, Vivian
Owusu-Dabo, Ellis
Ansong, Daniel
Osei-Akoto, Alex ..et.. al
Issue Date: 2017
Publisher: BMJ Open
Abstract: Introduction Sickle cell disease is highly prevalent in Africa with a significant public health burden. Nonetheless, morbidity and mortality in sickle cell disease that result from the progression of organ damage is not well understood. The Organ Damage in Sickle Cell Disease Study (ORDISS) is designed as a longitudinal cohort study to provide critical insight into cellular and molecular pathogenesis of chronic organ damage for the development of future innovative treatment. Methods and analysis ORDISS aims to recruit children aged 0–15 years who attend the Kumasi Centre for Sickle Cell Disease based at the Komfo Anokye Teaching Hospital in Kumasi, Ghana. Consent is obtained to collect blood and urine samples from the children during specified clinic visits and hospitalisations for acute events, to identify candidate and genetic markers of specific organ dysfunction and end-organ damage, over a 3 year period. In addition, data concerning clinical history and complications associated with sickle cell disease are collected. Samples are stored in biorepositories and analysed at the Kumasi Centre for Collaborative Research in Tropical Medicine, Ghana and the Centre for Translational and International Haematology, University of Pittsburgh, USA. Appropriate statistical analyses will be performed on the data acquired. Ethics and dissemination Research ethics approval was obtained at all participating sites. Results of the study will be submitted for publication in peer-reviewed journals, and the key findings presented at national and international conferences.
Description: This article is published in BMJ Open and is also available at doi:10.1136/bmjopen-2017-016727
URI: 10.1136/bmjopen-2017-016727
Appears in Collections:College of Agric and Natural Resources

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