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|Title: ||Helicobacter pylori Infection Is Associated with Higher CD4 T Cell Counts and Lower HIV-1 Viral Loads in ART-Naïve HIV-Positive Patients in Ghana|
|Authors: ||Sarfo, Fred Stephen|
Eberhardt, Kirsten Alexandra
Kuffour, Edmund Osei
Drexler, Jan Felix
Eis-Hübinger, Anna Maria
Oteng-Seifah, Emelia Efua
Phillips, Richard Odame
|Issue Date: ||24-Nov-2015|
|Publisher: ||Plos one|
|Citation: ||Sarfo FS, Eberhardt KA, Dompreh A, Kuffour EO, Soltau M, Schachscheider M, et al. (2015) Helicobacter pylori Infection Is Associated with Higher CD4 T Cell Counts and Lower HIV-1 Viral Loads in ART-Naïve HIV-Positive Patients in Ghana. PLoS ONE 10(11): e0143388. doi:10.1371/journal. pone.0143388|
|Abstract: ||Background ;
Worldwide, there is a high co-endemicity of HIV and H. pylori infection and there is growing evidence that H. pylori co-infection is associated with parameters of HIV disease progression.
The objective of this study was to investigate the prevalence of H. pylori infection, and
the association with clinical, immunological and virological parameters in a large cohort of
HIV-infected individuals and uninfected controls in a West African country.
HIV-patients (n = 1,095) and HIV-negative individuals (n = 107) were recruited at a university
hospital in Ghana. H. pylori status was determined using stool antigen testing. HIVrelated,
clinical and socio-demographic parameters were recorded and analyzed according
to H. pylori status.
The prevalence of H. pylori infection was significantly lower in HIV-positive compared to HIVnegative
individuals (51.5 vs. 88%, p<0.0001). In HIV patients, H. pylori prevalence decreased
in parallel with CD4+ T cell counts. In ART-naïve HIV-infected individuals, but not in those taking
ART, H. pylori infection was associated with higher CD4 cell counts (312 vs. 189 cells/μL,
p<0.0001) and lower HIV-1 viral loads (4.92 vs. 5.21 log10 copies/mL, p = 0.006). The findings
could not be explained by socio-demographic confounders or reported use of antibiotics.Having no access to tap water and higher CD4+ T cell counts were identified as risk factors for
H. pylori infection.
H. pylori prevalence was inversely correlated with the degree of immunosuppression. In
ART-naïve individuals, H. pylori infection is associated with favorable immunological and
virological parameters. The underlying mechanisms for this association are unclear and
|Description: ||An article published by Sarfo FS, Eberhardt KA, Dompreh A,
Kuffour EO, Soltau M, Schachscheider M, et al.
(2015) Helicobacter pylori Infection Is Associated with
Higher CD4 T Cell Counts and Lower HIV-1 Viral Loads in ART-Naïve HIV-Positive Patients in Ghana. PLoS ONE 10(11): e0143388. doi:10.1371/journal.pone.0143388|
|Appears in Collections:||College of Health Sciences|
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