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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/13388

Title: Dynamics of the Cytokine Response to Mycobacterium ulcerans during Antibiotic Treatment for M. ulcerans Disease (Buruli Ulcer) in Humans
Authors: Sarfo, Fred Stephen
Phillips, Richard Odame
Ampadu, E.
Sarpong, F.
Adentwe, E.
Wansbrough-Jones, Mark
Issue Date: Jan-2009
Publisher: Clinical and Vaccine Immunology
Citation: Clinical and Vaccine Immunology, Jan. 2009, p. 61–65, Vol. 16, No. 1 1556-6811/09/$08.00 0 ;doi:10.1128/CVI.00235-08
Abstract: We have studied the evolution of the gamma interferon (IFN- ) and interleukin 10 (IL-10) responses after Mycobacterium ulcerans sonicate stimulation of whole blood from patients with early M. ulcerans lesions during treatment with rifampin and streptomycin for 8 weeks. Among the 26 patients, secretion of IFN- increased during treatment, with a significant increase at 4 weeks and a further increase after 8 weeks overall. The increase was more rapid in patients with large or ulcerative lesions, becoming significant by 4 weeks. For small lesions, there was only a minor increase, which did not reach significance. There was no significant change in the median IL-10 response during antibiotic therapy, and there was no inverse correlation between IFN- and IL-10 responses. These results demonstrate that an IFN- secretory response to M. ulcerans developed, independently of IL-10 secretion, in patients whose M. ulcerans disease healed during antibiotic therapy
Description: An article published by Clinical and Vaccine Immunology, Jan. 2009, p. 61–65, Vol. 16, No. 1, 1556-6811/09/$08.00 0 ;doi:10.1128/CVI.00235-08
URI: http://hdl.handle.net/123456789/13388
Appears in Collections:College of Health Sciences

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