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Title: | Helicobacter pylori Coinfection Is Associated With Decreased Markers of Immune Activation in ART-Naive HIV-Positive and in HIV-Negative Individuals in Ghana |
Authors: | Eberhardt, Kirsten Alexandra Sarfo, Fred Stephen Dompreh, Albert Kuffour, Edmund Osei Geldmacher, Christof Soltau, Mareike Schachscheider, Marei ...et.al. |
Keywords: | HIV/AIDS Helicobacter pylori Immune activation Sub-Saharan Africa |
Issue Date: | 2015 |
Publisher: | Clinical Infectious Diseases |
Citation: | Clinical Infectious Diseases, 2015;61(10):1615–23; DOI: 10.1093/cid/civ577 |
Abstract: | Helicobacter pylori coinfection in human immunodeficiency virus (HIV) patients has been associated
with higher CD4+ cell counts and lower HIV-1 viral loads, with the underlying mechanisms being unknown.
The objective of this study was to investigate the impact of H. pylori infection on markers of T-cell activation in HIVpositive
and HIV-negative individuals.
Methods. In a cross-sectional, observational study, HIV patients (n = 457) and HIV-negative blood donors
(n = 79) presenting to an HIV clinic in Ghana were enrolled. Data on clinical and sociodemographic parameters,
CD4+/CD8+ T-cell counts, and HIV-1 viral load were recorded. Helicobacter pylori status was tested using a
stool antigen test. Cell surface and intracellular markers related to T-cell immune activation and turnover were quantified
by flow cytometry and compared according to HIV and H. pylori status.
Results. Helicobacter pylori infection was associated with decreased markers of CD4+ T-cell activation (HLADR+
CD38+CD4+; 22.55% vs 32.70%; P = .002), cell proliferation (Ki67; 15.10% vs 26.80%; P = .016), and immune
exhaustion (PD-1; 32.45% vs 40.00%; P = .005) in 243 antiretroviral therapy (ART)–naive patients, but not in 214
patients on ART. In HIV-negative individuals, H. pylori infection was associated with decreased frequencies of activated
CD4+ and CD8+ T cells (6.31% vs 10.40%; P = .014 and 18.70% vs 34.85%, P = .006, respectively).
Conclusions. Our findings suggest that H. pylori coinfection effectuates a systemic immune modulatory effect with
decreased T-cell activation in HIV-positive, ART-naive patients but also in HIV-negative individuals. This findingmight,
in part, explain the observed association of H. pylori infection with favorable parameters of HIV disease progression. |
Description: | An article published in Clinical Infectious Diseases, 2015;61(10):1615–23; DOI: 10.1093/cid/civ577 |
URI: | http://hdl.handle.net/123456789/13386 |
Appears in Collections: | College of Health Sciences
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