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Title: | Incident stroke among Ghanaians with hypertension and diabetes: A multicenter, prospective cohort study |
Authors: | Sarfo, Fred Stephen Mobula, Linda M. Plange-Rhule, Jacob Ansong, Daniel Ofori-Adjei, David |
Keywords: | Incident stroke Risk factors Prospective study West Africa |
Issue Date: | 2018 |
Publisher: | Journal of the Neurological Sciences |
Citation: | Journal of the Neurological Sciences, 395 (2018) 17–24 |
Abstract: | Background: The burden of stroke among hypertensive and diabetic population in sub-Saharan Africa remains
high. We sought to identify the risk factors associated with stroke occurrence in these high-risk population
groups.
Methods: A prospective cohort study involving adults with hypertension and or type II diabetes mellitus at 5
public hospitals in Ghana who were stroke-free at enrollment. Patients were followed every 2 months at clinic for
18 months and assessed clinically for first ever stroke by physicians. We calculated crude incidence rates for
stroke and assessed the factors associated with stroke occurrence using a multivariate Cox Proportional Hazards
regression models.
Results: Of 3220 eligible participants with 3805 person-years of follow-up, there were 54 clinically confirmed
new strokes. Incidence rate of stroke was 14.19 events per 1000 person-years [95% CI: 10.77–18.38], with rates
among diabetics with hypertension being 16.64 [10.58–25.00], hypertension of 13.77 [9.33–19.64] and diabetes
was 9.81 [3.59–21.74]. Two factors independently associated with stroke occurrence were previous cigarette
smoking with adjusted HR (95% CI) of 2.59 (1.18–5.67) and physical inactivity, 1.81 (1.06–3.10). In
secondary analysis, stage II hypertension compared with optimal BP was associated with aHR of 3.04
(1.00–9.27), p=.05 for stroke occurrence.
Conclusion: Incident stroke among Ghanaians with hypertension and diabetes is quite high. Stricter control of
blood pressure and engaging in regular physical activities are strongly recommended to reduce the risk of
strokes. |
Description: | An article published in Journal of the Neurological Sciences, 395 (2018) 17–24 |
URI: | http://hdl.handle.net/123456789/13346 |
Appears in Collections: | College of Health Sciences
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