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|Title: ||Post-stroke depression in Ghana: Characteristics and correlates|
|Authors: ||Sarfo, Fred Stephen|
|Keywords: ||Post-stroke depression|
Quality of life
|Issue Date: ||2017|
|Publisher: ||Journal of the Neurological Sciences|
|Citation: ||Journal of the Neurological Sciences, 379 (2017) 261–265|
|Abstract: ||Background: Poststroke depression (PSD) is prevalent and is an important determinant of functional recovery,
quality of life and mortality after stroke. Scanty data on the nature of PSD among stroke survivors in sub-Saharan
Africa prompted this study.
Objective: To assess the prevalence and predictors of depression in a convenience sample of Ghanaian stroke
Methods: We evaluated consecutive stroke survivors encountered at a comprehensive neurology clinic in a
tertiary medical center in Ghana. The Center for Epidemiologic Studies Depression Scale (CES-D) and Geriatric
Depression Scale (GDS) were both used to screen for depressive symptoms and subjects were considered as depressed
if they scored ≥16 on the CES-D scale and N5 on the GDS. Demographic and clinical data on stroke type
and severity aswell as health-related quality of life indicators were collected. Predictors of stroke-related depression
were assessed using a logistic regression model.
Results: Of 200 stroke survivors, mean ± SD age was 62.0 ± 14.4 years, and 105 (52.5%) patients were men.
Among the cohort 78.5% were classified as being depressed by CES-D, 42.5% by GDS, and 36.5% on both CES-D
and GDS. Inmultivariable analyses, for each unit increase on theModified Rankin scale (i.e. worsening disability),
there were higher odds of depression (adjusted OR 1.85; 1.28–2.69, p = 0.001), and being divorced (vs. being
married) was linked to depression (adjusted 2.82; 1.18–6.71, p=0.02). Stroke survivors with depression demonstrated
profound diminutions in the physical, psycho-social, cognitive and eco-social domains of quality of life
compared with those without depression (p b 0.05).
Conclusion: Almost 4 out of 10 stroke survivors in thisGhanaian cohort displayed clinically significant depression.
Prospective interventional studies are urgently needed to provide solid evidence-based and culturally tailored
interventions to address post-stroke depression particularly in LMICs.|
|Description: ||An article published in Journal of the Neurological Sciences, 379 (2017) 261–265|
|Appears in Collections:||College of Health Sciences|
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