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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/13335

Title: Pectin from Okra (Abelmoschus esculentus L.) Has Potential as a Drug Release Modifier in Matrix Tablets
Authors: Boakye-Gyasi, Mariam El
Owusu, Frederick William Akuffo
Entsie, Philomena
Agbenorhevi, Jacob K.
Banful, Ben Kwaku Branoh
Bayor, Marcel Tunkumgnen
Issue Date: 18-Jan-2021
Publisher: Hindawi, The Scientific World Journal
Citation: Hindawi, The Scientific World Journal; Volume 2021, Article ID 6672277, 10 pages; https://doi.org/10.1155/2021/6672277
Abstract: Natural polymers have become attractive to pharmaceutical researchers and manufacturers as excipients because of the advantages they possess relative to their semisynthetic and synthetic counterparts. Although pectin from some natural sources has been investigated for use in the pharmaceutical industry as excipients, pectin from okra, which is readily available and used as food in many parts of the world, has not been extensively investigated as a potential control-releasing agent in tablets. ,is study thus seeks to determine the drug release modifying properties of okra pectin from 6 different genotypes of okra cultivated and available in Ghana. Pectin was extracted from different genotypes of okra, physicochemical properties were characterized, and control release matrix tablets of metformin (F1–F6) were formulated using the wet granulation method with the okra pectin as the drug release modifier, respectively. ,e drug content, in vitro drug release, and mathematical kinetic modeling of drug release from the matrix tablets were studied. Drug release profiles of formulated matrix tablets were compared to an existing (innovator) brand of metformin sustained-release tablet on the market using the similarity and difference factors, respectively. ,e extracted pectin had percentage yields ranging from 6 to 20% w/w with swelling indexes and water-holding capacities between 300–500% and 9-10 mL/ g, respectively, and pH within 6.20–6.90. All the formulated batches passed the drug content test (90–105%) and produced the optimal release of metformin (>80%) after 24 hours. Different batches of formulated tablets exhibited different mechanisms of drug release with batches F1, F2, F5, and F6 being similar (f 2 values being >50 and f 1 values <15) to the innovator brand. Pectin from the 6 different genotypes of okra studied has the potential for use as drug release modifiers in pharmaceutical manufacturing of control release matrix tablets and production of more affordable medicines.
Description: An article published by Hindawi, The Scientific World Journal; Volume 2021, Article ID 6672277, 10 pages; https://doi.org/10.1155/2021/6672277
URI: http://hdl.handle.net/123456789/13335
Appears in Collections:College of Science

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