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|Title: ||Ethanolic stem bark extract of Terminalia ivorensis A. Chev. protects against potassium dichromate–induced nephrotoxicity in rats|
|Authors: ||Moomin, Aliu|
Mensah, Kwesi Boadu
Forkuo, Arnold Donkor
Adu-Gyamfi, Paa Kofi Tawiah
|Issue Date: ||2020|
|Publisher: ||Elsevier B.V. on behalf of African Institute of Mathematical Sciences / Next Einstein Initiative|
|Abstract: ||Objective: The plant Terminalia ivorensis is used in traditional medicine as a diuretic and
in the management of renal failure. We reported previously that the ethanol stem bark
extract of the plant protects against gentamicin-induced renal and hepatic damage in rats.
To further elucidate the mechanism of its renoprotective activity, we studied the effects
of the extract on Potassium dichromate–induced nephrotoxicity in rats. The present study
assessed the effectiveness of the ethanol stem bark extract of Terminalia ivorensis - against
renal oxidative injury evoked by potassium dichromate.
Methods: Adult Sprague Dawley rats pre-treated with (100–1000 mg/kg p.o. bwt) of Terminalia ivorensis extract for 5 days were challenged with a single dose of Potassium dichromate (20 mg/kg Sc) in the neck region on the 4th day. On the sixth day, renal function and
markers of oxidative injury were assessed.
Results: Terminalia ivorensis (300–1000 mg/kg p.o) pre-treatment dose dependently prevented decreases in urine output in rats challenged with a nephrotoxic dose of Potassium
Dichromate. The extract also protected the rats against Potassium dichromate-induced rise
in serum electrolytes, urea and creatinine. Furthermore, it dose dependently prevented
Potassium dichromate-induced decrease in renal glutathione (GSH) levels whereas tissue
oxidative enzymes Superoxide dismutase (SOD) and catalase were protected from damage.
Markers of lipid peroxidation such as level of renal Malondialdehyde (MDA) and myeloperoxidase (MPO) also decreased dose dependently when compare with Potassium dichromate
treated groups. The extract also protected the histomorphology of the kidney against Potassium dichromate induced damage.
Conclusion: The ethanol stem bark extract of Terminalia ivorensis protects kidney against
Potassium dichromate-induced renal damage|
|Appears in Collections:||College of Health Sciences|
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